Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Men with no sons more at risk for prostate cancer

08.01.2007
Cutting edge program examines men's reproductive health and role of fathers in risk for developmental disorders among offspring

In a new and unique study to determine if genes on the Y chromosome are involved in prostate cancer, researchers at Columbia University's Mailman School of Public Health in conjunction with Hebrew University of Jerusalem found that men who had only daughters had a higher risk of prostate cancer than men who had at least one son, thus signifying a possible defect on the father's Y chromosome. The results, published in the January 3, 2007 issue of the Journal of the National Cancer Institute, further indicate that the relative risk of prostate cancer decreases as the number of sons increases.

The researchers in the Mailman School's Department of Epidemiology analyzed the relative risk of prostate cancer by the sex of offspring among fathers registered in a family-based research cohort in Israel. From this cohort of 38,934 men, followed from the birth of their offspring (in 1964 through 1976) until 2005, the authors conclude that genes on the Y chromosome may be involved in prostate cancer risk in this population.

"We surveyed vital status and cancer incidence, and found a strong trend for a decrease in prostate cancer risk as the number of sons increased," said Susan Harlap, MD, professor of clinical Epidemiology at the Mailman School of Public Health, and the leader of the research team. "We anticipate that this finding will have a significant impact on the direction of research in this field going forward." Overall, there was a 40% increase in prostate cancer in men lacking sons.

The offspring's sex depends on whether it receives an X or a Y chromosome from the father. A man with a damaged Y chromosome will be less likely to have sons and those with a damaged X chromosome may be unable to sire daughters. "Our findings suggest that the biological significance of lack of sons – whatever it is that leads to increased risk of prostate cancer - becomes increasingly important as family size increases," observes Dr. Harlap. "Overall, our findings are consistent with hypotheses that tie Y chromosome loci to prostate cancer, although other explanations cannot be excluded," implies Dr. Harlap.

The researchers also looked at men lacking daughters. For example, in men with exactly two offspring, those with no daughters had an 11% increase in the incidence of prostate cancer, and those with no sons had a 47% increase, compared with men who had one son and one daughter. "The increased risk of prostate cancer in men with no daughters is probably due to chance," says Dr. Harlap, "but it might indicate a problem with a gene on the X-chromosome."

In addition to the Columbia University Mailman School of Public Health and Columbia University Department of Psychiatry, the international team of scientists included researchers from Hebrew University-Hadassah School of Public Health and the Braun School of Public Health, Jerusalem, Israel.

The Jerusalem Perinatal Cohort is among those being followed by the life course studies program within the Mailman School's Department of Epidemiology. Department Chair Ezra Susser, MD, DrPH, has been building a program of life course research -- called the Imprints Center -- in which epidemiologists seek to uncover the causes of a broad range of disease and health outcomes, by following individuals from an early point in life and examining their risks for disease. Life course studies are particularly well positioned to examine the interplay of genetic and environmental risk factors - the key to understanding many complex diseases.

Stephanie Berger | EurekAlert!
Further information:
http://www.columbia.edu

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>