Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study first: Over-expression of COX-2 can predict prostate cancer outcome

10.11.2006
Researchers say an over-expression of COX-2 in men with prostate cancer is associated with an increase in PSA after radiation treatment and the spread of the cancer outside of the prostate.

That is the result of the first study linking COX-2 (cyclooxygenase-2) with prostate cancer radiation treatment outcomes. The study, sponsored by the Radiation Therapy Oncology Group (RTOG 92-02), was presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia by Li-Yan Khor, M.D., a fellow in the Radiation Oncology Department at Fox Chase Cancer Center in Philadelphia.

"We found that an increased level of COX-2 prior to treatment was linked with biochemical failure and distant metastasis but was not predictive of overall survival," explained Khor.

For the study, Khor and colleagues analyzed 586 cases from RTOG 92-02 which had available tissue and suitable staining by immunohistochemistry. Median follow-up was 106.9 months. The intensity of COX-2 staining was quantified by automated image analysis provided by a commercial company.

The 5 year distant metastasis rate was 10.6 percent for a COX-2 intensity score less than 134, versus 14.1 percent for an intensity score greater than 134. A high intensity of COX-2 also predicted biochemical failure, the immediate PSA rise after treatment.

Khor added that data from animals have shown that inhibition of COX-2 suppresses angiogenesis (development of blood vessels) and the growth of prostate cancer, and is believed to make the cancer cells more sensitive to radiation therapy.

"This research suggest the need to know more about the levels of COX-2 in our patients," says Khor. "If men show increased levels of COX-2 perhaps radiation treatment will follow an attempt to inhibit COX-2 expression thereby making their cancer more responsive to radiation therapy."

Khor adds "Future studies in this area should include additional biopsy information to determine if COX-2 over-expression is associated with the inability to completely eliminate the cancer within the prostate."

Karen Mallet | EurekAlert!
Further information:
http://www.fccc.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>