"Radiation oncologists and urologists have been observing the PSA bounce for several years without knowing for sure if it had any clinical significance," explained Eric Horwitz, M.D., clinical director of the Radiation Oncology Department at Fox Chase Cancer Center and author of the study. Now we have a large body of evidence showing it doesn't."
PSA, or prostate specific antigen, is measured by a blood test and used to determine if prostate cancer is present.
One key endpoint of the study was to determine if there was a survival difference between the patients who experienced a PSA bounce and those who did not. The data evaluated were from two multi-institutional pooled datasets--4,839 patients (9 institutions) with early prostate cancer treated with external-beam radiation alone and 2,693 patients (11 institutions) treated with seed implants. The datasets for these men spanned an average of 10 years.
Of those who experienced a PSA bounce, 902 patients were treated with external-beam therapy and 470 patients were treated with seed implants, also known as brachytherapy. A PSA bounce was defined as an increase of at least 0.2 ng/ml over a previous PSA measurement followed by a decline.
"A significant number of men experienced at least one PSA bounce after treatment, usually within one to three years after treatment," said Horwitz. "However, after 10 years, there were no statistical differences in overall survival of patients who had a bounce and those who did not."
Horwitz said the study also showed no difference between the two groups regarding other clinically important endpoints, including biochemical failure (PSA level after treatment), distant metastasis-free survival and cause-specific survival. Biochemical failure was determined by the newest method--Nadir +2.
Karen Mallet | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
22.05.2018 | Life Sciences
22.05.2018 | Earth Sciences
22.05.2018 | Trade Fair News