Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Laser treatment not effective in preventing vision loss for people with early AMD

Researchers at Penn and other sites find no benefit of 35-year-old treatment

According to a study that appears in the November 2006 issue of the journal Ophthalmology, researchers at the University of Pennsylvania School of Medicine and 21 other clinical centers have found that low-intensity laser treatment - thought to be potentially beneficial in slowing or preventing the loss of vision from age-related macular degeneration (AMD) - is ineffective in preventing complications of AMD or vision loss. This is the major conclusion of the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) -a research study supported by grants from the National Eye Institute (NEI) of the National Institutes of Health (NIH).

According to the NEI, AMD is a disease associated with aging that gradually destroys sharp, central vision. Central vision is needed for seeing objects clearly and for common daily tasks such as reading and driving. People with early AMD have drusen - yellow deposits under the retina. The presence of drusen is the first sign of early AMD, and eyes with large drusen are at an increased risk of progressing to advanced AMD, with accompanying loss of vision.

"For the past 35 years, ophthalmologists have wondered about the advisability of employing preventive laser treatment for patients with large drusen who are at a high risk for vision loss and AMD," said Stuart L. Fine, MD, CAPT chairman and chair, Penn's Department of Ophthalmology; Director, Scheie Eye Institute. "We found that laser treatment had neither a clinically significant beneficial nor harmful effect for these patients. There is no evidence from this trial to suggest that people with large drusen should seek preventive laser treatment."

This was the first large-scale, multicenter study to evaluate the efficacy and safety of this technique. The study followed 1,042 participants over the age of 50 (average age of 71) who had 10 or more large drusen and visual acuity of 20/40 or better in each eye. One eye of each participant was treated, while the other eye was observed throughout the five years of the trial. After five years, 20.5% of the treated eyes and 20.5% of the untreated eyes had lost three or more lines of visual acuity on a standard eye chart.

Currently, the only established way to decrease the risk of vision loss in people with large drusen is daily supplements of vitamins and minerals. The NEI-sponsored Age-Related Eye Diseases Study (AREDS) reported in 2001 that a formulation which includes anti-oxidant vitamins (beta-carotene, Vitamin C and Vitamin E) and appropriate doses of zinc and copper could reduce the relative risk of progression from early to late AMD by 25% and reduce the relative risk of vision loss by 19%. The NEI recently launched AREDS2 to see if a modified combination of vitamins, minerals, and fish oil can further slow the progression of vision loss for AMD.

Kate Olderman | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>