Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Laser treatment not effective in preventing vision loss for people with early AMD

03.11.2006
Researchers at Penn and other sites find no benefit of 35-year-old treatment

According to a study that appears in the November 2006 issue of the journal Ophthalmology, researchers at the University of Pennsylvania School of Medicine and 21 other clinical centers have found that low-intensity laser treatment - thought to be potentially beneficial in slowing or preventing the loss of vision from age-related macular degeneration (AMD) - is ineffective in preventing complications of AMD or vision loss. This is the major conclusion of the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) -a research study supported by grants from the National Eye Institute (NEI) of the National Institutes of Health (NIH).

According to the NEI, AMD is a disease associated with aging that gradually destroys sharp, central vision. Central vision is needed for seeing objects clearly and for common daily tasks such as reading and driving. People with early AMD have drusen - yellow deposits under the retina. The presence of drusen is the first sign of early AMD, and eyes with large drusen are at an increased risk of progressing to advanced AMD, with accompanying loss of vision.

"For the past 35 years, ophthalmologists have wondered about the advisability of employing preventive laser treatment for patients with large drusen who are at a high risk for vision loss and AMD," said Stuart L. Fine, MD, CAPT chairman and chair, Penn's Department of Ophthalmology; Director, Scheie Eye Institute. "We found that laser treatment had neither a clinically significant beneficial nor harmful effect for these patients. There is no evidence from this trial to suggest that people with large drusen should seek preventive laser treatment."

This was the first large-scale, multicenter study to evaluate the efficacy and safety of this technique. The study followed 1,042 participants over the age of 50 (average age of 71) who had 10 or more large drusen and visual acuity of 20/40 or better in each eye. One eye of each participant was treated, while the other eye was observed throughout the five years of the trial. After five years, 20.5% of the treated eyes and 20.5% of the untreated eyes had lost three or more lines of visual acuity on a standard eye chart.

Currently, the only established way to decrease the risk of vision loss in people with large drusen is daily supplements of vitamins and minerals. The NEI-sponsored Age-Related Eye Diseases Study (AREDS) reported in 2001 that a formulation which includes anti-oxidant vitamins (beta-carotene, Vitamin C and Vitamin E) and appropriate doses of zinc and copper could reduce the relative risk of progression from early to late AMD by 25% and reduce the relative risk of vision loss by 19%. The NEI recently launched AREDS2 to see if a modified combination of vitamins, minerals, and fish oil can further slow the progression of vision loss for AMD.

Kate Olderman | EurekAlert!
Further information:
http://www.uphs.upenn.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>