Published in the December 1, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reviewed patient data from two different clinical trial protocols – to control for healthcare access biases – and found that African-Americans have tumors with poorer prognostic cellular characteristics and more aggressive clinical presentations, pointing to the possibility that racially influenced tumor biology may contribute to observed racial disparities in breast cancer outcome.
Population-based studies have demonstrated significant differences in breast cancer survival rates based on race, particularly among African-Americans who are more likely to die of their disease than Caucasians. However, other races have been poorly studied. An often hypothesized explanation is socioeconomic differences that impact healthcare and access. Recent data suggest, however, that there may be differences in the tumors at the cellular level that may contribute to poor clinical presentations and outcomes.
Led by Wendy A. Woodward, M.D. of the University of Texas M. D. Anderson Cancer Center in Houston, researchers reviewed medical records and outcome data from 2,140 Caucasian, Hispanic and African-American breast cancer patients enrolled in clinical trials, controlling for differences in treatment that compromise other studies. Patients were either treated with chemotherapy before (neoadjuvant) or after (adjuvant) mastectomy.
The researchers found that in both treatment groups African-American race was independently associated with poor tumor and clinical characteristics and low survival rates compared to both Caucasian-Hispanic cohorts. For example, African-Americans presented with more advanced disease and were likely to have estrogen-receptor negative tumors. Analysis to control for other confounding factors confirmed that African-American race by itself was associated with lower survival in both treatment groups.
This study, conclude the authors, supports previous data "that African-American women more frequently had ER-negative disease and high-grade tumors and that African-American race was associated with a poorer survival rate." This was confirmed in "two independent data sets of patients treated on prospective protocols."
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences