Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pediatric heart condition's origin, prevalence mirror adults

19.10.2006
The mystery behind a commonly untreatable and undetected heart muscle disease in children is partially revealed for the first time in today's edition of the scientific journal JAMA.

In a multi-center, international study, researchers at Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) in Houston showed the underlying causes, frequencies, and outcomes of dilated cardiomyopathy (DCM), which often leads to heart failure, paralleling those in adults with DCM. The study also found DCM to be more common among boys of all races and in blacks compared to whites.

"Children with dilated cardiomyopathy are at the same level of risk as adults of having sudden cardiac death and needing transplants," said senior author Dr. Jeffrey Towbin, professor of pediatrics at BCM and chief of pediatric cardiology at TCH. "It is a major cause of death in children just like it is in adults."

Funded by the National Heart, Lung, and Blood Institute, one of the National Institutes of Health, the study identified the causes in 35 percent of the 1,400 cases of pediatric DCM studied, the most common one being myocarditis (inflammation of the heart). The origins of the roughly two-thirds of cases studied were unknown. Infants (less than one year old) were almost ten times more likely to develop DCM than any other pediatric age group (up to 18 years old) studied.

Survival rates for children with DCM were also found to be approximately the same as in adults with the condition. In both groups, around 70 percent live beyond the first year of the disorder's onset, and only 50 percent survive past five years.

DCM, the most common form of cardiomyopathy at any age, occurs when the left ventricle, the heart's major pumping chamber, becomes enlarged and cannot pump effectively, usually resulting in heart arrhythmia, heart failure, and the possible need for a heart transplant. Other forms of cardiomyopathy are characterized by the heart's inability to relax appropriately between pumps, and their outcomes are commonly sudden, unexpected cardiac death.

Roughly one-third of all cases of DCM are genetic in origin. Towbin recommends that people with a family history of DCM be tested for the disorder.

"Even though we can't always determine what the cause is, we know if it's inherited," Towbin said. "With an early diagnosis, we can begin therapy and assess whether transplantation is necessary."

Although these findings represent a major stride toward better understanding and treating DCM, Towbin says much work remains.

"Despite advances in diagnosis and treatment, we are still having significant problems with outcomes in these children just like we are in adults," said Towbin. "There needs to be more support for research in this area."

Ross Tomlin | EurekAlert!
Further information:
http://www.bcm.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>