Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibiotic gives hope to patients with IBS

18.10.2006
Rifaximin is the first possible treatment for the potential causative factors of IBS

A new study found that patients reported greater global improvements in irritable bowel syndrome (IBS) symptoms and less bloating after taking rifaximin than patients taking placebo. The randomized, double-blind study is the first to demonstrate a sustained benefit of an antibiotic for IBS symptoms after treatment is stopped.

The study, "The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowl Syndrome," is published in the October 17, 2006, issue of Annals of Internal Medicine. The entire article is available to the public on October 17, 2006, at http://www.annals.org/cgi/content/full/145/8/557.

IBS is one of the most common chronic medical conditions – affecting about 15 to 20 percent of the population. Its cause is unknown but some IBS patients exhibit an overabundance of bacteria in the small bowel of the colon.

"This is the first possible treatment for the potential causative factors of IBS," said Mark Pimentel, MD, FRCP(C), Director, GI Motility Program, Cedars-Sinai Medical Center, the study's lead author. "Patients can take the antibiotic for a brief period of time and experience benefit for ten weeks."

In the study, 87 patients with IBS between the ages of 18 and 65 received 1200 mg of rifaximin (an antibiotic that works in the gut without being absorbed into the blood stream) a day or a placebo for 10 days. Patients reported their symptoms for the next 10 weeks.

More than 50 percent improvement in symptoms was reported by more patients who took rifaximin (37.2 percent) than by those who took placebo (15 percent). However, the researchers did not detect a difference in symptoms of diarrhea or constipation. Rifaximin is FDA approved for the treatment of travelers' diarrhea.

The nonabsorbed antibiotic seems to cause few side effects, another benefit for patients.

"Rifaximin doesn't get into the blood stream and interact with other medications," Dr. Pimentel said.

The drug helped patient Cynthia Greenspan get her life back.

"After the first five days of taking the medication, I started feeling better," said Greenspan. "After 10 days, I couldn't believe how much better I felt."

The researchers caution that while the study demonstrates improvement for a relatively small group of IBS patients, side effects may be difficult to assess in such a small study when considering the potentially large patient population with IBS. A larger and longer study is necessary to evaluate the effects of treatment for other symptoms, such as constipation.

In a separate editorial, Douglas A. Drossman, M.D., wrote, "Demonstrating benefit from a short course of an antibiotic for a sustained period of time in unselected patients with IBS is certainly novel and important."

Steve Majewski | EurekAlert!
Further information:
http://www.acponline.org

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>