Using data from the Multiethnic Cohort Study, V. Wendy Setiawan, Ph.D., assistant professor of preventive medicine at the Keck School of Medicine of USC, and her colleagues determined that of the five primary ethnicities/races in the cohort, native Hawaiians have the highest risk of breast cancer--65 percent greater than whites. They also had some of the highest levels of circulating estrogens.
"We had observed that some groups, such as native Hawaiians have higher breast cancer rates compared to white women. We knew hormones are a factor, so we decided to test them," says Setiawan. "The research seems to support that idea."
The researchers also found that Japanese-American women have comparatively high estrogen levels and the second highest breast cancer risk of the five groups. "This is interesting because breast cancer rates have been increasing steadily in Japanese women who live in the United States, as well as in women who live in Japan," Setiawan says. "We think it could be caused by lifestyle changes that impact age at first menstruation or other factors."
Latinas had similar hormone profiles to whites, while women who had recently immigrated had slightly lower levels, but which were not statistically significant, the researchers found. However, Latinas' risk of breast cancer is the lowest of the groups studied.
One of the most interesting findings was that African-American women have a slightly lower post-menopausal breast cancer risk than whites, despite having comparatively higher post-menopausal hormone levels.
"It is known that before menopause, African-American women have a higher breast cancer risk than whites, as well as higher estrogen levels," Setiawan says. "It would be interesting to find out why their elevated rates do not persist after menopause, despite having comparatively higher estrogen levels."
The researchers analyzed the hormone levels in 739 postmenopausal women in the cohort who were not on hormone replacement therapy. After adjusting the hormone levels for age, body mass index, and other lifestyle factors, they then compared the levels to their ethnic/racial groups' breast cancer incidences. The study is the largest analysis of hormone levels by ethnic group, and the first large study of native Hawaiians and Latinas.
"Clearly, more work is needed to identify factors that contribute to racial and ethnic differences in hormone levels," Setiawan says.
Kathleen O'Neil | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences