After the mice returned to breathing normal air, they quickly returned to normal. These changes were expected, based on the Seattle research. But the physiologists found something they did not expect. Normally, as oxygen consumption goes down and heart rate decreases, blood pressure decreases also. Since the heart rate of the mice fell by more than 50%, the researchers expected blood pressure to fall, but it didn't, Ichinose said.
Surprisingly, blood pressure stays normal
"We were surprised to find that blood pressure didn't change, even though the mouse's heart beat fell to 200 beats per minute," Volpato said. "We don't know why, but it may be a physiological response to maintain body temperature," Ichinose added.
An animal's blood pressure needs to remain at a certain level to ensure blood reaches the vital organs. Normally, a mouse with that heart rate would have very low blood pressure and would be close to death. But these mice returned to normal two hours after the gas was discontinued.
The researchers then repeated the experiment with a new set of mice, but this time they raised the "room" temperature from 27° C (81° F) used in the first experiment, to 35° C (95° F). They found that heart rate and respiration rate still fell significantly, but not as much as the first experiment when the room was cooler.
They also found that in the warmer room, blood pressure increased, whereas it had remained unchanged in the colder environment. The researchers also measured the cardiac output of the mice in this experiment by echocardiography, and found that stroke volume, that is, the amount of blood the mice pumped with each beat, was unchanged by the gas. However, total cardiac output decreased because the heart was beating much slower.
Could help surgery patients
"These findings demonstrate that mice that breathe 80 parts per million of hydrogen sulfide become hypothermic and decrease their respiration rate, heart rate and cardiac output without affecting stroke volume or mean arterial pressure," the authors said.
This line of research could have a variety of helpful applications, including sustaining the function of organs of critically ill people, Ichinose said. It may also be possible to use the finding for patients undergoing surgery. This would be an advance, because anesthesia usually causes blood pressure to drop.
"Currently, hypothermia is the only proven way to decrease metabolic rate and confer some protection when blood flow to the organs is impaired or intentionally reduced, such as during complex cardiac surgery," Ichinose said. "However, hypothermia has some adverse effects, including depressing cardiovascular functions and blood clotting. If we can figure out how hydrogen sulfide reduces metabolic rate without depressing myocardial function, we may be able to reduce metabolism and protect organs without using hypothermia."
One caveat to this research so far is that hydrogen sulfide might produce this result in mice and other naturally hibernating species much more readily than other species, including humans, Ichinose said. The researchers intend to extend the study to bigger animals, such as sheep and pigs to see if they have the same cardiac and hemodynamic reaction. "If the same thing happens in those species that would be much more interesting," Ichinose said.
Christine Guilfoy | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy