Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Child-proof: Brain mapping safer for children than previously thought

09.10.2006
Dispelling a stubborn myth, researchers at Johns Hopkins have shown that children with strokes, brain tumors and other cerebrovascular diseases can safely undergo a potentially life-saving brain-mapping test that many doctors have long shunned over concerns for side effects.

Analysis of 241 cerebral angiograms performed on 205 children at the Johns Hopkins Children's Center between 1999 and 2006 showed that not a single patient suffered complications during or immediately following the procedure.

Results of the analysis, believed to be the first study in more than 25 years to look at the safety of cerebral angiographies in children, are reported in the October issue of Stroke.

Performed by threading a catheter into the patient's groin, through the abdomen and the chest and upward into the arteries of the neck, cerebral angiography is the most accurate brain-vessel imaging technique available and a critical diagnostic and treatment tool, says Lori Jordan, M.D., a pediatric neurologist at the Children's Center and a co-author of the report.

"The assumption that angiographies in children are more dangerous than in adults has persisted over the years-mostly due to lack of evidence," says study senior author Philippe Gailloud, M.D., an interventional neuroradiologist at Johns Hopkins. "When we ask parents to sign consent for an angiography, their first question is how safe it is, and up until now, we didn't have any hard data to show them. Given the very low risk of complications we see, pediatric neurologists should not hesitate to order the procedure, and we can say to them that we have research showing this procedure is indeed very safe in children."

The most dreaded complication of the procedure is accidental damage to a blood vessel that can cause a stroke.

"This is an invasive procedure, so obviously physicians must be careful in determining how appropriate it is in a child, but as doctors, we should keep in mind that we shouldn't deny the potentially crucial assistance of an invasive procedure because of overblown assumptions of danger," Gailloud says.

Delayed diagnosis and treatment are also dangerous, and sometimes fatal, Gailloud notes, particularly in cases of ischemic stroke caused by a clot or lack of blood supply to the brain vessels; hemorrhagic stroke, caused by a ruptured brain vessel that bleeds into the brain; and brain tumors and certain types of malformations of blood vessels in the brain, which also may rupture and bleed. "An angiogram is absolutely critical when a child has suffered an unexplained bleeding in the brain," he adds.

Among those studied, a single death occurred three hours after an angiogram and was attributed to bleeding in the brain that the patient had suffered before admission to the hospital, the Hopkins team said. None of the patients developed blood clots in the groin, a common and potentially dangerous complication of puncturing the femoral artery, and none reported leg pain, difficulty walking or limping during an average follow-up of 28 months.

While most angiograms are diagnostic, they can also be used to treat spinal and brain malformations endovascularly-or from within the blood vessel-and thus offer a less-invasive alternative to neurosurgery for certain conditions.

In some cases, diagnosis is possible with noninvasive imaging tests such as CT scans or magnetic resonance imaging (MRI), but these tests can give false-positive or false-negative results, meaning they would diagnose a problem where there is none or fail to detect one.

"Unfortunately, we don't know how often noninvasive tests are missing or misdiagnosing something," Jordan says. "We do know that angiography is clear."

Compared to doing the test in adults, the procedure in children usually takes less time because they have fewer other medical conditions that might cause complications, Jordan adds. In addition, technological advances over the past 20 years, such as smaller, softer catheters and guided imagery also make angiograms in children safer.

Each year, about 3,200 children suffer a stroke, up to half of whom develop permanent cognitive or motor disabilities. About one-third of them will have another stroke, and up to one-fifth of affected children will die. Risk factors for stroke in children include heart disease, sickle-cell anemia, some blood-clotting disorders, vascular malformations, and viral infections, such as varicella, HIV and others.

Katerina Pesheva | EurekAlert!
Further information:
http://www.jhmi.edu
http://www.hopkinschildrens.org

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>