Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers examine why food tastes bad to chemotherapy recipients

21.09.2006
About two million cancer patients currently receiving certain drug therapies and chemotherapy find foods and beverages to have a foul metallic flavor, according to a medical study. In general, more than 40 percent of hospitalized patients suffer from malnutrition due to taste and smell dysfunction.

"Unfortunately, these problems that impact nutrition and quality of life are underestimated and understudied by oncologists," said Andrea Dietrich, Virginia Tech professor of civil and environmental engineering (CEE).

Dietrich believes there are two components to the metallic flavor –– the taste of metal ions on the tongue and the production of metal-catalyzed odors in the mouth that create a retro-nasal effect. "I am attempting to gain a better understanding of the metallic sensation, its prevention, and application to human health," Dietrich said.

Along with two of her university colleagues, Susan E. Duncan, professor of food science and technology, and YongWoo Lee, an assistant professor in the biomedical sciences and pathology department and a member of the Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Dietrich is the recipient of a $200,000 grant from the Institute of Public Health and Water Research (IPWR) to examine the problems of foul flavored water. The interdisciplinary investigative team combines proficiency in food oxidation and off-flavors, water chemistry, cell biology, and human perception.

Dietrich, the principal investigator on the project, is an expert on water quality and treatment, as well as its taste and odor assessment. In fact there are some 33 identified flavors of drinking water acknowledged by the American Water Works Association and Research Foundation (AwwaRF). They range in description from "wet paper" to "crushed grass" to "peaty" to "plastic."

Several years ago, AwwaRF sponsored Dietrich to travel around the U.S. to educate utility staff and managers on how to use sensory analysis to detect changes in water quality. She is also a co-developer of three odor-testing methods for the daily monitoring of raw and untreated water.

Now she is hoping to work with medical personnel as she, Duncan, and Lee compare the sensory thresholds, recommended nutritional levels, and adverse health effect levels of iron and copper in water, and their relationship to health-based problems such as persistent metallic tastes of patients receiving chemotherapy.

They hope to identify the cause of the metallic flavor in the mouth when drinking water contains metal ions, specifically iron and copper. Their research will also evaluate the use of antioxidants to prevent the metallic flavor production. "If we can discover the cause of the production of metallic flavor, then preventive methods can be taken accordingly," Dietrich said.

In correct amounts, metals in drinking water are actually important sources of micronutrients in the human diet. In fact, iron and copper are commonly found in drinking water, and they can be an important source of these mircronutrients. However, there are thresholds. If ingested at higher concentrations, greater than three milligrams per liter, iron and copper "may cause nausea, vomiting, diarrhea, kidney and liver damage," Dietrich explained.

Some tests will be done with human volunteers to determine reactions of volatile compounds in the mouth. Since saliva contains proteins and enzymes, it may have some effect in enhancing the metallic flavor. They will also use in-vitro experiments in order to conduct experiments at higher concentrations without endangering anyone, Dietrich added.

Perception of taste and odor is very complex, and like nutritional needs, varies depending on age, gender, race, health status, prior exposure and experience.

Two graduate CEE students, Pinar Omur-Ozbek and Jose Cerrato, both of Blacksburg, Va., will work on this project.

Lynn Nystrom | EurekAlert!
Further information:
http://www.vt.edu

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>