The results of the study designed to determine the long-term benefits and risks of anti-inflammatory drugs in patients undergoing hip replacement surgery were published today in the British Medical Journal. The study specifically measured the effects of a short post-operative course of anti-inflammatories on the development of 'ectopic' bone formation related pain and disability, six to twelve months after surgery.
"Ectopic bone is abnormal bone that can form in the soft tissues around the operated hip. This occurs in more than one third of all patients in the months after hip replacement surgery," explained, Dr Marlene Fransen Head, Musculoskeletal Program at The George Institute and Principal Investigator of this study. Many surgeons prescribe anti-inflammatory drugs in the immediate post-operative period to avoid this outcome, or simply as part of a pain management strategy. While the researchers found the use of post-operative ibuprofen, a common anti-inflammatory drug, did indeed greatly reduce the risk of ectopic bone formation, patients reported no greater reductions in hip pain or physical disability six to twelve months after surgery, compared with those not taking the drug. However, they also found evidence suggesting there may be an increased risk of major bleeding events in those taking the drug,
"For this reason, our study shows that recommending a routine course of an anti-inflammatory drug following hip replacement surgery, is not justified."
Chronic osteoarthritis of the hip is common among Australians aged 60 years or older and total hip replacement surgery is a well-established and highly effective treatment. Whilst joint replacement surgery greatly reduces chronic hip pain and improves physical function in most, residual symptoms are common. Over 900 patients from 20 orthopedic surgery centres across Australia and New Zealand participated in this study, half of whom were allocated to receive ibuprofen, a common anti-inflammatory drug, for 14 days commencing immediately after surgery.
"These results provide further evidence that guidelines for routine clinical care in surgery must be based on clinically important outcomes. Without such evidence, the widespread use of routine anti-inflammatory-based treatment after major orthopaedic surgery may well result in harm rather than benefit," Dr Fransen added.
Emma Orpilla | EurekAlert!
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Earth Sciences
11.12.2017 | Information Technology