Using mouse models, in vivo and in vitro tests revealed that the overexpression of a cell-regulating gene called cyclin D1 may actually be advantageous for some breast cancer patients because it suppresses the activity of another gene--STAT3--which promotes cell overgrowth and prevents harmful cells from dying, explains Doris Germain, PhD, Assistant Professor of Medicine.
Dr. Samuel Waxman, the Albert A. and Vera G. List Professor of Medicine, and Clinical Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences, Yuki Ishii, PhD, the study's first author and a post-doctoral fellow in molecular oncology, and Dr. Germain, collaborated with colleagues from Mount Sinai, and researchers from the Dana-Farber Cancer Institute in Boston and the Peter MacCallum Cancer Centre in Melbourne, Australia. They found that high levels of cyclin D1 increases sensitivity to bortezomib, a recently approved FDA drug used to treat multiple myeloma. The findings indicate that cyclin D1 could be a potential biological marker to help clinicians predict which breast cancer patients would respond favorably to bortezomib.
"Tumors occur because of a lack of control over cellular division," Dr. Germain explains. "Cyclin D1 promotes cell growth so you would think it would be an advantage to the tumor. But instead, we found that when cyclin D1 is overexpressed, it blocks STAT3. So cyclin D1 is inhibiting STAT3, which in turn, keeps the cancer from developing further."
Repressing STAT3 also increased a breast tumor's sensitivity to bortezomib, adds Dr. Waxman, indicating that bortezomib may be an alternative for women whose breast cancer has high levels of cyclin D1. "Our study provides a potential explanation for the beneficial effect of cyclin D1 in breast cancer and suggests that by amplifying this effect, bortezomib may be a useful treatment," he says. "A genetic profile of a patients' breast tumors could yield a great deal of information and help clinicians create more targeted treatments for their patients."
The findings were a surprise, Dr. Waxman says, because previous studies had suggested that the overexpression of cyclin D1 was associated with a poor prognosis in other types of cancers, including pancreatic cancer. Dr. Waxman says more research is needed to ascertain which groups of women have overexpressed cyclin D1. Clinical trials could then determine whether bortezomib would benefit these patients, he adds.
Mount Sinai Press Office | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Earth Sciences
25.04.2017 | Life Sciences
25.04.2017 | Earth Sciences