Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chronically high blood sugar linked to risk of cognitive impairment

11.08.2006
A four-year study of elderly women has found that chronically elevated blood sugar is associated with an increased risk of developing either mild cognitive impairment (MCI) or dementia.

The study was the first to investigate the association over time between glycosylated hemoglobin – a long-term measure of blood sugar – and the risk of cognitive difficulties, and the first to investigate that association in people without diabetes. It appears in the Volume 10, Number 4 issue of the Journal of Nutrition, Health, and Aging.

“We already know there’s a connection between diabetes and cognitive problems,” says lead author Kristine Yaffe, MD, a staff physician at the San Francisco VA Medical Center and a professor of psychiatry, neurology, and epidemiology at the University of California, San Francisco. “We were interested in what this measurement would tell us about a group of women with and without diabetes who were followed for four years. Nobody has really looked at that before.”

The glycosylated hemoglobin test measures the percentage of hemoglobin – the oxygen-bearing protein in red blood cells – that is bound to glucose. Unlike the standard diabetic blood sugar test, which measures blood sugar at the moment of testing, glycosylated hemoglobin is considered an accurate measure of blood sugar levels over the course of two to four months preceding the test. A result of seven percent or less indicates good long-term blood sugar control.

The researchers studied 1,983 post-menopausal women with a mean age of 67 years. Their baseline glycosylated hemoglobin levels were tested at the beginning of the study, and they were assessed for dementia every year for four years. At the end of the study, each one percent increase in glycosylated hemoglobin at baseline was associated with a 40 percent increased risk of developing MCI or dementia four years later.

Women with a glycosylated hemoglobin of seven percent or higher at baseline were four times more likely to develop MCI or dementia than women who tested at less than seven percent.

When the 53 women in the study known to have diabetes at baseline were excluded from the results, there was still a statistically significant association between elevated glycosylated hemoglobin and the risk of MCI or dementia.

The authors conclude, “This finding supports the hypothesis that abnormal glycemic control is linked to an increased risk of developing cognitive impairment and dementia in elderly women.”

The authors note that there are a number of possible reasons why chronically high blood sugar may cause cognitive impairment, ranging from the overall effects of diabetic complications to direct and indirect brain damage caused by high blood sugar to a possible association between the enzyme that degrades insulin and the development of Alzheimer’s disease.

“Type 2 diabetes is a very common and growing problem,” notes Yaffe. “The point is that now you can identify people who are at risk for MCI or dementia and monitor them closely with glycosylated hemoglobin. I think we need to take these people who are at risk and see whether we can target them for trials or interventions for better blood glucose control.”

Co-authors of the study were Terri Blackwell, MS, of California Pacific Medical Center; Rachel Whitmer, PhD, of Kaiser Permanente Division of Research; Katherine Kreuger, MD, of Eli Lilly and Company; and Elizabeth Barrett-Connor, MD, of UC San Diego.

The research was supported by grants from the National Institutes of Health, the Mount Zion/UCSF Fund for Women’s Health, and the Paul Beeson Faculty Scholars in Aging. The parent trial, of which the current study was a part, was funded by Eli Lilly and Company.

SFVAMC has the largest medical research program in the national VA system, with more than 200 research scientists, all of whom are faculty members at UCSF.

UCSF is a leading university that consistently defines health care worldwide by conducting advanced biomedical research, educating graduate students in the life sciences, and providing complex patient care.

Steve Tokar | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>