This year, more than 213,000 American women will learn they have breast cancer. Many women with early stage cancer prefer to have a lumpectomy, where only the cancerous lump is surgically removed, followed by radiation therapy and possibly chemotherapy. With a lumpectomy, the surgeon removes the tumor along with some healthy, non-cancerous tissue nearby. Doctors then examine it under a microscope. If the outside of the tumor, or margin, is free of cancer, it's considered to be a negative margin. If the outside of the tumor has cancer cells present, it's considered a positive margin. When it's unclear, or a very small distance, doctors call it a close margin. Women with a positive or close margin often require more surgery to make sure all the cancer is removed. This surgery is called a re-excision. Most patients with close or positive margins would be advised to undergo re-excision.
In this study conducted at Fox Chase Cancer Center in Philadelphia, doctors divided 1,044 patients with stage I-II breast cancer with close or positive margins into three groups. Group 1 included 199 patients who did not have additional surgery, group 2 had 546 patients who had additional surgery proving they were free from cancer and group 3 included 299 patients who had additional surgery and showed evidence of additional cancer. All patients received radiation therapy.
After 10 years, the number of local recurrences was the same for women who had re-excision and for women who did not have re-excision (group 1 versus groups 2 and 3 together). However, the result of the re-excision helped predict whether women would have their cancer return. Women with no residual disease at the time of re-excision (group 2) had a local control of 95 percent, while women found to have residual disease in the breast (group 3) had a local control of 91 percent.
"This study helps to clarify the role of a re-excision for a close or positive margin in women undergoing breast-conserving therapy for early-stage breast cancer," said Derek Chism, M.D., lead author of the study and a radiation oncologist now practicing at North Shore Medical Center in Peabody, Mass.
Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Awards Funding
26.10.2016 | Power and Electrical Engineering
26.10.2016 | Health and Medicine