Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Paternal-side family history of breast cancer may be missed

26.07.2006
Could contribute to inaccurate screening

Taking a family history is one of the most accessible genomic screens for breast cancer. However, a history of cancer on the paternal side may not be as well reported. In a study published in the September issue of the American Journal of Preventive Medicine, researchers from the Virginia Commonwealth University Massey Cancer Center and the University of Washington, Seattle found that subjects reported fewer family members with breast cancer on their father's side than their mother's. The authors point out that on a population basis, women should have equal numbers of maternal and paternal extended relatives (not including mothers) with breast cancer. This under-reporting could have serious consequences for the accuracy of screening for breast cancer.

Using survey data from April 2003 to March 2005 for Women's Health Clinic patients without breast cancer, researchers found that while 16% of the participants reported a maternal relative with breast cancer, only 10% reported a paternal relative. Because mothers are much more likely to develop breast cancer than fathers, participants who reported a mother with breast cancer were excluded from the study.

There may be multiple explanations for this unexpected discrepancy. For this particular study, the family histories might be accurate. This would lead to a conflict with current thinking about the inheritance of breast cancer risk. Alternatively, excessive reporting of maternal cancers could have affected the data, but earlier studies of family history indicate that breast cancer reporting tends to be accurate. Finally, men may not be aware of familial breast cancer risk and may not communicate this information to their relatives. This factor could be important where fathers are not present in the home or are unknown to the child. This would contribute to inaccuracy of family history, although misinformation (as opposed to lack of information) about paternity should not affect the maternal– paternal ratio.

Writing in the article, John M. Quillin, PhD, suggests, "The most likely explanation for these findings may be under-reporting of breast cancer on the paternal side. Future studies are needed to look for modifiable explanations (e.g., genetics education, family communication specifically for maternal and paternal relatives, or medical documentation) of the discrepancy in the reporting of family history of breast cancer to improve the sensitivity of the family history screen."

Dr. Quillin continues, "Disease prevention scientists need to be mindful of this discrepancy when using reported family history to design and implement breast cancer health interventions. Primary care physicians might pay particular attention to getting information about the father's side of the family since patients may not know that paternal family history is also relevant for their health."

Charlotte Seidman | EurekAlert!
Further information:
http://www.ucsd.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Molecular Force Sensors

20.09.2017 | Life Sciences

Producing electricity during flight

20.09.2017 | Power and Electrical Engineering

Tiny lasers from a gallery of whispers

20.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>