Malaria is one of the leading causes of death worldwide, causing an estimated 3,000 deaths each day and at least 300 million cases of severe illness each year, particularly among infants in sub-Saharan Africa. Prior attempts at prevention that relied on frequent administration of antimalarial drugs were unaffordable in the long run and might promote drug resistance. But intermittent preventive treatment, a more focused use of antimalarials at a few specific intervals, has proved promising in earlier studies.
Clara Menendez, MD, and her colleagues in Mozambique and Spain explored the intermittent administration of the antimalarial sulfadoxine-pyrimethamine (SP) to infants in their first year. Infants given SP at 3, 4, and 9 months of age were compared with those given a placebo at the same intervals.
Dr. Menendez and colleagues found that giving infants SP was safe and well tolerated, and reduced the incidence of hospital admissions by one fifth.
According to editorialists Feiko O. ter Kuile, MD, PhD, of the Liverpool School of Tropical Medicine and the U.S. Centers for Disease Control and Prevention, and Richard W. Steketee, MD, MPH, of the Malaria Control and Evaluation Partnership in Africa, "SP has a combination of features that may make it highly suitable for use as intermittent preventive treatment; it has relatively long half-lives, is very well tolerated in young infants, and it can be given as a single dose."
Intermittent preventive treatment with sulfadoxine-pyrimethamine is seen by Drs. ter Kuile and Steketee to provide a satisfactory balance of safety and efficacy. There is "substantial protective efficacy of this approach," they said.
Steve Baragona | EurekAlert!
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine