Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

REM sleep behaviour disorder is an early marker of neurodegenerative diseases

29.06.2006
The front page of the July 2006 issue of The Lancet Neurology, the journal with the highest international impact, contains a work that shows the relationship between disorders during REM sleep and future neurodegenerative pathologies.

This study has been conducted by a Hospital Clínic group led by Dr. Àlex Iranzo. This study is a good example of the fact that a correct diagnosis of sleep disorders by a specialist group can achieve a high relevancy. This diagnosis is possible in the Hospital Clínic thanks to the Multidisciplinary Unit of Sleep Disorders, which is in operation since May 2003, and which consists in 17 specialists from five areas, namely, neurology, psychiatry, psychology, otorhinolaryngology, and pulmonology.

This organisation permits a multidisciplinary approach with high resolution tests, department clinical protocols and sessions, with a clear optimisation of resources. The most frequent pathologies treated in this unit are sleep apnoea, snoring, REM sleep behaviour disorders, narcolepsy, night epilepsy or hypersomnia. Only last year, 3,809 visits, 1,819 sleep tests and 40 surgical interventions were made in the unit.

As well as clinical and teaching areas, this unit has high research activity as shown by the study explained below. This work has been led by Dr. Àlex Iranzo, member of the Unit of Neurology of Hospital Clínic and of the Functional Studies of the Nervous System Group of the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Not only The Lancet Neurology published the work, but also it dedicates the front page to the article, and a reflection by Canadian neurologists Dr. Ronald Postuma (Department of Neurology of the Montreal General Hospital de Québec) and Dr. Jacques Montplaisir (Centre D’Etude du Sommeil in the Hospital du Sacre-Coeur de Montreal).

This article is based in a descriptive study conducted since 1991 in which 44 patients from the Unit of Sleep Disorder of the Hospital Clínic were assessed. Given the low incidence of this disorder, the sample of patients studied by this Catalan group is the highest until today. All these patients presented idiopathic REM sleep behaviour disorder. These patients, usually over 60 years, suffer from unpleasant dreams and express uneasiness by screaming, crying, kicking, punching and even falling from their beds.

According to the results of this study, 20 of these patients (45%), after being correctly diagnosed in the centre and followed up during five years, developed a neurodegenerative disease. This incidence is much higher than what is expected in the general population of the same age and gender. Therefore, scientists drew the conclusion that this disorder permits the early detection of neurodegenerative diseases such as Parkinson’s disease, Lewy body dementia, multiple system atrophy or mild cognitive impairment. Furthermore, the fact that the twenty patients who developed a neurodegenerative disease were those who had suffered from REM sleep behaviour disorder for the longest time, suggests that this incidence could be superior in the future.

The importance of these results lie firstly in the future possibility of administrating neuroprotective drugs to patients with the REM sleep behaviour disorder who have still not developed a degenerative disease. Furthermore, the monitoring of these patients will permit an early administration of palliative drugs, which are already available. Toward this end, the Ministry of Health has awarded this group with a FIS award named “Prognostic markers of the development of a neurodegenerative disease in patients affected with REM sleep behaviour disorder”.

Àlex Argemí Saburit | alfa
Further information:
http://www.idibaps.ub.edu/

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

The RWI/ISL-Container Throughput Index started off well in 2018

22.02.2018 | Business and Finance

FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation

22.02.2018 | Health and Medicine

Histology in 3D: new staining method enables Nano-CT imaging of tissue samples

22.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>