Prof. Maksymowych, Division of Rheumatology, University of Alberta, Edmonton, Canada, and his radiologist colleagues recognized the importance of image-guided IA steroid placement for accurate treatment and the significant effects this might have on the clinical responses in an earlier trial showing that the treatment was not effective. Precision image-guided injections can be very helpful and at times are essential to help localize the structural origin of a patient’s pain, especially in places where it might be difficult to detect the pain source, such as in the hip and the spine.
OA is the most common type of arthritis affects approximately 2.95 women per 1000 population and approximately 1.71 men per 1000 population.2 The typical symptoms of hip OA are stiffness, as well as pain, which is usually felt in the groin, but may radiate to the knee, buttock, or inner thigh, and is mainly felt on weight-bearing and aggravated by movement. Over time, the patient might get increased stiffness and might find it difficult to reach down to tie shoe laces, or put on socks and shoes. The functional ability may also progress to difficulties in rising from a chair, using stairs, walking and dressing.
The 52 patients enrolled in the trial, received fluoroscopically guided IA injection and were randomly allocated placebo (2 ml of normal saline) or 40 mg of the treatment (triamcinolone hexacetonide). Assessments were performed at baseline, one and two months post-injection. The study found that the patients given steroids improved significantly compared to placebo in all primary and secondary endpoints; pain, stiffness, physical function and global assessment, after 2 months.
“This is very encouraging data, which I believe will have a great response in the medical community. Because there is no cure, the therapeutic goal of treatment for osteoarthritis is to minimize the effects of the disease and its consequences over time. The study shows that the treatment with steroids offers many patients with late stage OA some hope of pain relief when conservative therapy has failed”, said Prof. Maksymowych.
Mia Gannedahl | alfa
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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