Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Race affects prostate cancer survival rates

12.06.2006
Japanese American men respond better to hormonal treatment for prostate cancer and have a much higher survival rate than white American men, according to research published in the latest issue of the UK-based urology journal BJU International.

A team of researchers from the US and Japan compared 59 white males and 105 Japanese American males who had receive hormone treatment for prostate cancer at The Queen’s Medical Centre in Honolulu, Hawaii.

They discovered that, although there was little difference between the patients’ backgrounds and ages, five years after the treatment started the overall survival rate for the Japanese American patients was 66 per cent, compared with 42 per cent for the white men in the sample.

The result between the two ethnic groups did not appear to be affected by whether the men’s cancer was confined to the prostate or had spread to other parts of the body.

However the survival rates tended to even out in the most advanced cancers, when the levels of the Prostate-Specific Antigen (PSA) protein produced by the prostate exceeded 100. About a quarter of the study sample had PSA readings in this range.

“Japanese men have one of the lowest rates of prostate cancer worldwide, but levels tend to be higher among Japanese American men, compared with those who actually live in Japan” says lead author Dr Takashi Fukagai, a urologist at the Showa University School of Medicine in Tokyo.

“One theory is that Japanese Americans retain some native Japanese genetic and,or,lifestyle characteristics that lead to them developing prostate cancer less frequently than white American men.

“We also have a ongoing study of other ethnic groups, which has shown that Chinese men living in Hawaii have a similar prognosis to Japanese American men. We have also discovered that Filipino men have a worse prognosis than those two ethnic groups, but still enjoy a higher survival rate than white men.

The men who took part in the study had an average age of 76 and had all received hormonal treatment from the same team or urologists. Hormone therapy blocks the action of the male sex hormones that help the cancer cells grow, either through administering testosterone lowering drugs or by removing the testosterone-producing testicles.

None of the study subjects had received definitive surgical or radiation therapy.

Five factors were examined in detail – age, race, pre-treatment PSA score, the clinical stage that the cancer had reached and the Gleason score, which defines the severity of the cancer based on microscopic analysis.

Only two factors - race and the pre-treatment PSA score – were shown to have a significant effect on whether the patient survived and for how long.

“One of the reasons why the survival rate may be better among Japanese American men with a PSA of less than 100 is that they are less likely to suffer from the side-effects of the hormone treatment, such as heart problems, compared with white American males” adds Dr Fukagai.

“There is also evidence that different races have different genetic profiles. As prostate cancer is a disease that is affected by hormones, it may be that the nature of the actual disease, and how it progresses, varies between different races.

“However prostate cancer undergoes various changes as it develops and we suspect that the changes that take place in the advanced stages of the disease reduce the effect of those ethnic differences.

“This would account for the fact that there was a difference in survival rates between Japanese American and white men with a PSA of less than 100, but those ethnic differences disappeared in more severe cases with a PSA of more than 100.”

Annette Whibley | alfa
Further information:
http://www.bjui.org

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>