Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UAB, Yale Researchers Determine Two Surgical Interventions for Preemies Have About the Same Effectiveness

30.05.2006


Neither of the two emergency surgical interventions used to correct perforated necrotizing enterocolitis (NEC), a common and dangerous complication of prematurity, appears to significantly improve an infant’s survival and later health, according to a study by UAB researchers and colleagues in the May 25 issue of The New England Journal of Medicine.



In the first clinical trial to examine this issue, a team of scientists from UAB, Yale University and other sites studied 117 preterm infants with perforated NEC to compare outcomes of the two currently used surgical interventions, primary peritoneal drainage, or laparotomy, and bowl resection. All study infants were born before 34 weeks gestation and weighed less than 1,500 grams (3.31 pounds).

“We found that the type of operation performed for perforated NEC does not influence survival or other clinically important outcomes in preterm infants,” said Reed A. Dimmitt, M.D., M.S.P.H., UAB assistant professor of pediatrics and co-author of the study. “My colleagues and I believe that with the results of this study, surgeons will continue to perform the operation they are most comfortable with, but we hope it spurs discussion of alternative operations with scientific non-bias.”


“This is the first clinical trial to compare to two different emergency surgical treatments in babies,” added Douglas C. Barnhart, M.D., UAB assistant professor of surgery and also co-author of the study. “The completion of this trial is a landmark for clinical research in pediatric surgery.”

Perforated NEC is a gastrointestinal disease involving infection and inflammation that causes destruction of the bowel or part of the bowel. It affects one in 2,000 to 4,000 of all births.

In severe cases of NEC such as those in this study, a hole, or perforation, may develop in the intestine, allowing bacteria to leak into the abdomen and causing life-threatening infection called peritonitis. With mortality rates approaching 50 percent in infants who weigh less than 1,500 grams, NEC represents a significant clinical problem.

“Once NEC has progressed to needing an operation, it is almost too late,” Dimmitt added. “These results demonstrate the vital need for research to study the mechanism of disease and additional trials designed to prevent NEC.”

Jennifer Park Lollar | EurekAlert!
Further information:
http://www.uab.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>