Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds stool testing novel technique for detecting colon cancer

23.05.2006


Researchers at Mount Sinai School of Medicine have found that an improved version of the non-invasive fecal DNA (fDNA) test to screen for colon cancer (CRC) demonstrates a higher sensitivity for detecting cancers of the colon. This data will be presented at the Digestive Disease Week (DDW) conference on May 21, 2006 in Los Angeles.



Previous studies have shown that a first generation fDNA test (PV1) was effective in the detection of colon cancer but partial degradation of DNA was a limitation. Using a second-generation test, the research team, led by Dr. Steven Itzkowitz, primary goal was to determine the sensitivity (SENS) and specificity (SPEC) of the new test in patients with known CRC and those with normal colonoscopies (NL). Compared to PV1 data, the addition of buffer and gel-capture technology, as well as new markers of colon cancer, increased test sensitivity for cancer detection to 88%.

"This is an exciting achievement for this technology. Fecal DNA testing has already shown promise for non-invasive tool for colon cancer detection. But, we can now say this test is more sensitive which ultimately means better results for the clinician and the patient. Better tests mean greater detection and less loss of life," said Steven Itzkowitz, M.D., Professor and Associate Director of Gastroenterology at The Mount Sinai Medical Center. "The fact that the new version of the test includes fewer markers makes the new test even easier to perform."


Patients in this prospective multi-center study were enrolled and consented after colonoscopic findings of either a normal colon (n=122) or CRC (n=40). Patients had no personal or family history of CRC or polyps. Approximately 6-14 days after colonoscopy (prior to surgery for the CRC group), patients submitted a single stool sample to which they had immediately added buffer and then shipped the specimen by express courier to the clinical lab. Stools were homogenized and DNA was extracted using sequence-specific gel-capture.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Antarctic landscape insights keep ice loss forecasts on the radar

20.11.2017 | Earth Sciences

Filling the gap: High-latitude volcanic eruptions also have global impact

20.11.2017 | Earth Sciences

Water world

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>