Two new studies from the Johns Hopkins Childrens Center show that computerizing ordering of chemotherapy and other types of intravenous drug infusions for children greatly reduces the risk of potentially dangerous medical errors.
An online infusion calculator and a computerized drug ordering system, developed under the leadership of Christoph Lehmann, M.D., director of clinical information technology at the Childrens Center, have been in use there for about three years, but this is the first time that researchers have measured their impact on medication errors.
Children in general are three times more likely than adults to be victims of medication errors because both ordering and dosing are more complex in children than adults, according to Lehmann. In children, dosing is based on calculations factoring in age, height and weight, and miscalculations and rounding errors could cause life-threatening harm. Dosing errors also cause more ill effects in children because still-developing bodies absorb, metabolize and excrete drugs at different rates than adults and thus have lower tolerance for medication overdose. Children undergoing treatment for cancer are at even greater risk because the general dangers of potent chemicals are compounded by the dosing challenges.
Katerina Pesheva | EurekAlert!
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Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
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Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
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