A new study of women with early stage, localized breast cancer identifies new patterns and risk factors for invasive disease that may influence how patients are treated. Published in the May 15, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reveals that patients with lobular carcinoma in situ (LCIS) are actually at higher risk of developing advanced stage tumors than previously thought. In addition, women with ductal carcinoma in situ (DCIS) who are under 50 years old, African-American or Hispanic are at increased risk of developing advanced stage invasive tumors.
In situ lesions, such as DCIS and LCIS, are early generation cancer cells that have not yet invaded adjacent tissue. The diagnosis of DCIS and LCIS has been increasing up to 7-fold since 1980, according to U.S. statistics. The increase is hypothesized to be due primarily to more screening mammograms and breast biopsies.
The significance of these confined lesions in the course of breast cancer continues to be explored. Current research indicates that DCIS and LCIS clinically have different courses and prognoses, and consequently, should have different treatments. Oncologists recommend surgery for DCIS, considered a precursor to same breast invasive cancer. In contrast, observation after biopsy is recommended for uncomplicated LCIS, which is thought to have little invasive risk but may be a risk factor for later breast cancer. A few small studies have suggested that LCIS has a risk for same and contralateral invasive tumors, prompting some to recommend bilateral mastectomy in high risk patients.
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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