Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Thinner and younger

05.04.2006


Preliminary study demonstrates calorie restriction reduces markers of aging



Can eating a low-calorie yet nutritionally balanced diet extend human life? Preliminary research suggests it might, so researchers at Washington University School of Medicine in St. Louis are launching a long-term study to find out.

In an editorial in the April 5 issue of the Journal of the American Medical Association, Luigi Fontana, M.D., Ph.D., assistant professor of medicine at Washington University and an investigator at the Istituto Superiore di Sanita in Rome, Italy, says calorie-restricted diets point to possible mechanisms of aging and suggest ways to intervene and modify its effects.


In January, Fontana and colleagues found that after an average of six years on calorie restriction, people’s hearts functioned like the hearts of much younger people. And a team from the Pennington Biomedical Research Center at Louisiana State University in Baton Rouge is reporting that six months of calorie restriction reduces two key markers of aging: fasting insulin levels and body temperature.

More than a decade ago several researchers, including John O. Holloszy, M.D., professor of medicine at Washington University, demonstrated that stringent and consistent caloric restriction increased the maximum lifespan in mice and rats by about 30 percent and protected them against atherosclerosis and cancer.

Human study has been difficult because calorie restriction requires a very strict diet regimen, both to keep the total number of calories low and to insure that people consume the proper balance of nutrients. Some people from a group called the Calorie Restriction Society are devoted to limiting their caloric intake in hopes of improving their health and extending their lives. Society members, who call themselves CRONies (Calorie Restriction with Optimal Nutrition), have developed ways to eat low calorie/high nutrition diets.

Fontana has done extensive research with CRONies, most recently reporting in the Jan. 17 issue of the Journal of the American College of Cardiology that the hearts of people on calorie restriction appeared more elastic than those of age- and gender-matched control subjects. Their hearts were able to relax between beats in a way similar to the hearts of younger people.

The team from the Pennington Biomedical Research Center reports in the April 5 issue of the Journal of the American Medical Association on a six-month study of men and women between 25 and 50 who were placed on a calorie restriction diet that lowered their daily caloric intake by about 25 percent. The researchers compared those on calorie restriction to subjects who either had not been on a diet, had cut calories by about 12.5 percent and increased the energy they burned through exercise by a like amount, or had spent six months on a standard low-calorie diet of about 1,800 to 2,000 calories per day until they had lost 15 percent of their body weight.

The study, called the Comprehensive Assessment of the Long Term effects of Reducing Intake of Energy (CALERIE), found that all subjects who dieted or increased their exercise lost weight and body fat. But those on a calorie restriction diet ended the study with lower fasting insulin levels and lower core body temperatures. They also had less oxidative damage to their DNA, thought to be a marker of aging at the biochemical and cellular level.

"This study has laid the groundwork for future research into the long-term effects of calorie restriction in humans to see whether it really can extend lifespan," Holloszy says. "It’s becoming clear from studies with the CRONies -- and from this brief, prospective study -- that calorie restriction does change some of the markers we associate with aging."

Holloszy and Fontana are getting ready to launch a second phase of the CALERIE study, to look at the effects of calorie restriction over the course of two years.

"We know people on calorie restriction will lose weight," says Fontana. "But this study isn’t a weight-loss study. We’re hoping to learn more about whether calorie restriction can alter the aging process.

Fontana says, for example, that low-grade, chronic inflammation seems to mediate aging. Overweight and obese people tend to have higher levels of inflammation than lean people, so it makes sense that losing weight might increase average lifespan by lowering the risks of some age-related diseases, such as diabetes and atherosclerosis. But in animal studies not only did more of the animals live longer, the maximum length of a rat’s or mouse’s life also increased. The CALERIE study hopes to get some clues about whether calorie restriction might do the same thing for humans.

"We want to learn whether calorie restriction can reverse some of these markers of aging in healthy young people," Holloszy says. "It’s going to be many years before we know whether calorie restriction really lengthens life, but if we can demonstrate that it changes these markers of aging, such as DNA damage and inflammation, we’ll have a pretty good idea that it’s somehow influencing the aging process at the cellular level."

Currently, Holloszy and Fontana are beginning to recruit volunteers for Phase II of the CALERIE study.

Jim Dryden | EurekAlert!
Further information:
http://www.wustl.edu

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>