Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Targeted therapies showing great promise against colorectal cancer

04.04.2006


Results from a Phase III study of a new drug show promise for patients with colorectal cancer that has spread to other parts of the body, according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research.

Investigators have shown that panitumumab improves progression-free survival in patients with metastatic colorectal cancer (mCRC) who had failed standard chemotherapy. In the randomized trial of 463 patients, those who received panitumumab with best supportive care every two weeks (231 pts) showed a 46 percent decrease in the rate of tumor progression or death versus those who received only best supportive care (232 pts). At week 24, approximately four times as many pantimumab patients were alive and progression-free versus those on best-supportive care (18 percent versus five percent). Twice as many panitumumab patients were alive and progression-free at week 32 (10 percent versus four percent).

Study investigators also reported that panitumumab significantly improved disease control. In patients who responded, the median duration of response was 17 weeks. Extended follow-up also revealed that even after 32 weeks, a larger percentage of patients in the panitumumab with best supportive care group were alive without progression than in the group assigned to best supportive care alone.



"We are encouraged by these results, particularly that panitumumab was well-tolerated in patients with metastatic colorectal cancer, with very few major adverse reactions," said Marc Peeters, M.D., Ph.D., coordinator of the Digestive Oncology Unit, from Ghent University Hospital in Belgium.

Recently, researchers have begun to focus their efforts on developing cancer therapies that are not only effective, but also are easier on the body than current therapies. Using newer therapies that are derived from human protein sequences, investigators are finding that the body is less likely to develop side effects from these drug,s such as allergic reactions.

Panitumumab is the first fully human monoclonal antibody that targets the epidermal growth factor receptor (EGFr), a protein that plays an important role in cancer cell signaling. EGFr activates when naturally occurring proteins in the body, such as epidermal growth factor (EGF), bind to it and trigger signals to encourage cell growth. Panitumumab binds to EGFr, preventing the natural protein from binding to it and interfering with the signals that would otherwise stimulate growth of the cancer cell and allow it to survive.

"Studies involving the use of panitumumab alone and in combination with other therapies for various cancers may confirm that the use of human monoclonal antibodies is a great step forward to effectively treat cancer," said Dr. Peeters.

The most common side effect was rash, and other lesser side effects included fatigue, nausea and diarrhea. No anti-drug antibody formation was observed.

*Abstract No. CP-1: A Phase 3, Multicenter, Randomized Controlled Trial (RCT) of Panitumumab Plus Best Supportive Care (BSC) vs. BSC Alone in Patients (pts) with Metastatic Colorectal Cancer (mCRC)

Warren Froelich | EurekAlert!
Further information:
http://www.aacr.org

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>