Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Virginia Tech research finds Swedish method of human cartilage repair shows good durability

30.03.2006


As the population ages, arthritis will become more prevalent. It would be helpful to know more about the causes and treatments of cartilage wear.



Michael Furey, Virginia Tech professor emeritus of mechanical and biomedical engineering, recently conducted the first study of wear in human cartilage. Furey will report his research and results at the 231st American Chemical Society National Meeting in Atlanta March 26-30.

Furey has been studying lubrication and wear of cartilage for 20 years. Many years ago, he took a one-year sabbatical to work at the Boston Children’s Hospital Medical Center to carry out studies of cartilage wear using bovine cartilage. He demonstrated the importance of fluid biochemistry on wear. In one example, a complex protein isolated by David Swann reduced cartilage wear by 90 percent when added to a saline reference fluid-a level equaling that of normal bovine synovial fluid.


For the last eight years, Furey and Hugo P. Veit, professor of pathobiology in the Virginia – Maryland Regional College of Veterinary Medicine at Virginia Tech, and their students have continued the research on the biochemistry of cartilage wear based on bovine cartilage.

While Furey and his group at Virginia Tech had been developing methods of measuring cartilage wear, Mats Brittberg of the Cartilage Research Unit of Goteborg University had developed methods of cartilage repair, including autologous chondrocyte implantation (ACI). But the Swedish group had no idea how long the repair would last -- days, weeks, months, years? Thus, three years ago a collaboration was born to conduct what the two groups believe is the first research of human cartilage wear under controlled "in vitro" conditions.

Brittberg’s ACI method involves taking small samples of healthy cartilage from a patient’s damaged joint, culturing the tissue in a Petri dish under controlled conditions to allow millions of chondrocyte cells to grow, and then injecting these cartilage cells into the specially-prepared damaged region. The Swedish ACI process has been used on thousands of patients and Brittberg continues his work on developing improvements in cartilage repair. "But the basic and important question remained: How long will the repair last?" Furey said.

"Funding from the Carilion Biomedical Institute supported a collaborative study with the Swedish group," said Furey. "Mats sent us cartilage biopsies from eight Swedish patients -- a sample of healthy cartilage and repaired cartilage from each. Since the specimens were very small -- only two millimeters (mm) in diameter compared to our usual six mm diameter bovine specimens -- new techniques and holders were developed by Nils Steika, the graduate student on the project and a mechanical engineering major."

"The results showed that Brittberg’s ACI method produced repairs of excellent durability," said Furey.

"But additional research is needed in this area of tissue engineering. Conventional repair methods such as abrasion arthroplasty gave significantly higher wear than that of normal cartilage. Articular cartilage, consisting of about 80 percent water, is deceptively simple. But it is very complex and still not completely understood.

"In general, papers from the medical area are strong on joint, arthritis, and biochemistry but weak on mechanics, particularly tribology -- the study of friction, wear, and lubrication," said Furey. "On the other hand, many papers on this topic in the engineering area, although strong on mechanics, are weak on or omit biochemistry. Our group has an advantage in that we fully appreciate the importance of tribology and of biochemistry in the process," he said. "For example, we have shown time and time again that there is absolutely no correlation between cartilage wear and friction -- a point that is often missed by researchers on this topic".

Susan Trulove | EurekAlert!
Further information:
http://www.vt.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>