Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Single dose of azithromycin prevents recurrence of inturned eyelashes

14.03.2006


A Johns Hopkins Medicine study finds that a single dose of the oral antibiotic azithromycin taken after trichiasis eye surgery can reduce the frequency with which eyelashes turn back in and abrade the eye. The oral antibiotic treatment is more effective than multiple days of treatment with the topical antibiotic ointment Tetracycline, the current method of treatment after trichiasis surgery.



Trichiasis is the leading infectious cause of blindness worldwide. It is a condition in which the eyelid turns inward and the eyelashes rub against the eye, causing corneal scarring, that can lead to blindness. It results from years of repeated episodes of trachoma, an ocular bacterial infection that is very common in rural areas of developing countries.

The bacteria that cause trachoma are suspected to be spread by contact with hands or clothing of infected individuals. Flies may also transfer the infection from one person to another. Because trachoma is transmitted through close personal contact, it tends to occur in clusters, often infecting entire families and a large majority of people in a given community. The disease usually remains hidden in rural areas of developing countries where people live in overcrowded conditions with limited access to water and health care.


Trichiasis can be corrected by appropriate lid surgery, which returns the inturned eyelashes to their normal position. However, even under the best of circumstances the eyelashes may turn back in (between 16 percent and 50 percent within a few years after surgery). That’s why this new Johns Hopkins research is so valuable, says lead researcher Sheila West, Ph.D., of the Dana Center for Preventative Ophthalmology at Johns Hopkins Medicine. In the current study, less than 10 percent of people had their eyelid turn in again within one year after surgery.

In the study, published in the March 2006 issue of the Archives of Ophthalmology, the research team found that a single dose of the antibiotic azithromycin reduces the risk of trichiasis recurring for up to one year after surgery.

The researchers compared the use of one oral dose of azithromycin to six weeks of twice daily topical tetracycline treatment. Researchers found the azithromycin group had one-third fewer recurrences of inturned lashes than the tetracycline group.

"We are delighted with the results of this study. Trichiasis plagues the poorest of the poor, and primarily affects the most underprivileged members of the community, the women. The results of this study have major implications for improving outcomes of trichiasis surgery. The use of a single dose of azithromycin is a relatively straightforward and simple procedure to implement, and in many countries the drug is provided through a free donation program." says West. "Not only have we shown that azithromycin can reduce recurrence, but we have also demonstrated that in the hands of well-trained individuals trichiasis recurrence can be below 10 percent. These results set a new standard for trichiasis surgery and are applicable throughout the world."

John M. Lazarou | EurekAlert!
Further information:
http://www.jhmi.edu
http://www.hopkinsmedicine.org/wilmer/index.html
http://www.nei.nih.gov

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>