Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Large European study finds gene variant is no strong risk factor for osteoporosis

21.02.2006


Variations in a number of different genes and environmental factors affect an individual’s risk for osteoporosis. Several gene variants have been linked to osteoporosis, but few have stood the test of time. The GENOMOS study, a large European collaboration led by Andre Uitterlinden (Erasmus University Medical Center), John Ioannidis (University of Ioannina), and Stuart Ralston (University of Edinburgh), now shows that a top candidate gene plays a role in osteoporosis, but with effects that are less marked than those described in previous studies.



The so-called Sp1 polymorphism in the COL1A1 gene is a plausible candidate: the gene contains the genetic information to make type 1 collagen, a major component of bone, and preclinical studies suggested that one of the two variants (the T version) led to weaker bones. Earlier genetic studies had found an association between the T variant and low bone mineral density (BMD) and fractures, prompting some scientists to suggest that genetic testing of people for this variant could help in assessing fracture risk. The GENOMOS study was done to evaluate how good the COL1A1 genetic test was at predicting fractures and to determine if it was associated with osteoporosis.

Over 20,000 people took part in GENOMOS, and the number of fractures reported was five times greater than in all previous studies combined. The researchers conducted genetic testing for the COL1A1 variation in participants and measured bone mineral density in all of them. The link between the T variant and osteoporosis was less impressive than that found in many earlier studies. The Sp1 polymorphism in COL1A1 was associated with reduced BMD, but the effects were small and limited to people who carried two copies of the T variant. The investigators found an association between the T variant and spine (vertebral) fractures, but there was no association with non-spine fractures. Overall, the researchers estimate that the presence of the T allele would explain at most 10% of the risk of vertebral fractures for women.


From these results, it seems clear that genetic testing for the COLIA1 variant in isolation would be premature and would not be sufficient to accurately identify people at risk of fractures. It is likely that researchers will need to develop tests that involve studying the variants in several genes (and possibly other variants in the COL1A1 gene) and use them in combination with standard methods of risk assessment such as BMD measurements, before they can usefully predict a substantial fraction of an individual’s risk for osteoporosis.

Andrew Hyde | EurekAlert!
Further information:
http://www.plosmedicine.org

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New Method of Characterizing Graphene

Scientists have developed a new method of characterizing graphene’s properties without applying disruptive electrical contacts, allowing them to investigate both the resistance and quantum capacitance of graphene and other two-dimensional materials. Researchers from the Swiss Nanoscience Institute and the University of Basel’s Department of Physics reported their findings in the journal Physical Review Applied.

Graphene consists of a single layer of carbon atoms. It is transparent, harder than diamond and stronger than steel, yet flexible, and a significantly better...

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

3D printer inks from the woods

30.05.2017 | Life Sciences

How circadian clocks communicate with each other

30.05.2017 | Life Sciences

Graphene and quantum dots put in motion a CMOS-integrated camera that can see the invisible

30.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>