Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


MRI drug may improve cancer-killing ability of chemotherapy, study says


A contrast agent currently used in magnetic resonance imaging (MRI), called mangafodipir, may increase the cancer-killing ability of some chemotherapy drugs while protecting normal cells, according to a study in the February 15 issue of the Journal of the National Cancer Institute .

Many anticancer drugs work by increasing the levels of tumor cell hydrogen peroxide. Tumor cells are particularly sensitive to hydrogen peroxide and die as a result. However, certain enzymes in the body can work to protect cells from this kind of damage, rendering certain cancer drugs less effective. In addition, the drugs are toxic to normal cells. The drug mangafodipir, a contrast agent given to patients before they have an MRI, helps promote the production of hydrogen peroxide while at the same time, through different biologic mechanisms, protects healthy cells from the negative effects of oxidative damage.

Jérôme Alexandre, M.D., of the Groupe hospitalier Cochin-Saint Vincent de Paul in Paris, and colleagues exposed tumor cells and white blood cells from 10 cancer patients and white blood cells from six control subjects to three chemotherapy drugs--paclitaxel, oxaliplatin, and 5-fluorouracil--in the presence or absence of mangafodipir. They also studied the effects of mangafodipir on colon cancer cells in mice treated with paclitaxel.

The authors found that mangafodipir protected the white blood cells taken from healthy volunteers and from cancer patients. The drug also protected paclitaxel-treated mice from infection that would cause a lowered white blood cell count and helped increase the cancer cell-killing ability of the chemotherapy drug paclitaxel against the cancer cells in mice.

"Our results support investigation of the use of mangafodipir in cancer patients, because mangafodipir may enhance the therapeutic index of anticancer agents by both protecting normal cells and increasing antitumoral activity of these agents," the authors write. "The safety of mangafodipir administered as a contrast agent in magnetic resonance imaging has already been demonstrated."

In an accompanying editorial, James H. Doroshow, M.D., of the National Cancer Institute, suggests that clinical trials may be the next approach for studies of drugs such as mangafodipir that affect oxidative stress in tumor cells. He writes, "Overall, this study contributes to our rapidly developing understanding of tumor cell [oxidation-reduction] balance and to the possibility that therapeutic approaches to the modulation of oxidant-mediated growth control may be possible in the near future, perhaps with mangafodipir or with other [oxidation-reduction] modulators in development."

Ariel Whitworth | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>