Less than 1 percent of outpatients who received medication in 2002 were prescribed a medication that violated a prescription drug’s black box warning, according to a study in the February 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
"Adverse drug events (ADEs) are believed to be among the leading causes of mortality in the United States, with an estimated 100,000 deaths per year," according to background information in the article. However, there is little U.S. data on the occurrence of potentially dangerous drug-drug, drug-laboratory, and drug-disease interactions in outpatients. Black box warnings are separate, highlighted messages on drug labels that were developed by the Food and Drug Administration to help physicians avoid serious ADEs.
Karen E. Lasser, M.D., M.P.H., of Cambridge Health Alliance and Harvard Medical School, Cambridge, Mass., and colleagues, examined data from 51 outpatient practices to see how often physicians prescribed drugs in violation of black box warnings. The researchers analyzed electronic health records of 324,548 outpatients who received at least one prescription between January 1 and December 31, 2002.
Alison Harris | EurekAlert!
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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