Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gap widens between optimal versus actual cholesterol levels

06.02.2006


An estimated 63 million adults have low-density lipoprotein cholesterol (LDL-C) levels higher than what would be ideal as recommended by the National Institutes of Health.



Of that group, 38 million are people with health conditions that put them at increased risk for cardiovascular disease.

These findings, by Stephen D. Persell and co-researchers at Northwestern University Feinberg School of Medicine, are reported in the February issue of the Journal of General Internal Medicine. Persell, who led the study, is assistant professor of medicine at the Feinberg School.


The study, which compared 2001 NIH cholesterol level targets with revised, more stringent, optimal targets issued in 2004, found that 10 million more adults had LDL-C ("bad cholesterol") levels above the new targets.

The new guidelines recommend that physicians strive to get patients’ LDL-C levels lower, particularly for those at moderately high and high risk for heart disease.

"Nationally, we are far from achieving the 2001 goals, and as new evidence leads the NIH to push optional goals down further, the gap between what we believe to be ideal goals and what has been achieved gets even wider," Persell said.

Too much LDL-C can build up on the inner lining of arteries that feed the brain and heart, and in conjunction with other substances form plaques (deposits) that can clog vessels and cause a stroke or heart attack.

In combination with cardiovascular disease risk factors, such as high blood pressure, diabetes, tobacco smoking and/or family history of heart disease, high levels of LDL-C put individuals at increased risk for heart disease.

The goal for high-risk (heart disease or diabetes) patients is an LDL-C level was less than 100. However, a level of 70, rather than 100, is suggested in updated recommendations for those who are at very high risk for cardiovascular disease.

The new optional goal for those at moderately high risk is 100, compared to the 2001 goal of 130.

The study notes that despite the fact that nearly all persons in the high-risk group have LDL-C levels that are too high, 25 percent of them already use cholesterol-lowering medications, such as statins.

The study shows that many more people would need drug therapy to reach the recommended LDL-C levels, but it notes that a substantial number are unlikely to achieve these goals with standard-dose statins.

Current costs may also place those drugs out of reach for many patients. At current retail prices, a year’s supply of 40 milligrams daily of generic lovastatin can cost $450 to $700. Costs per patient would be even higher if name-brand statins or high-dose statins and combination drug therapy are used.

The updated guidelines, published in July 2004, were based on a review of five major clinical studies of statin therapy conducted after the 2001 guidelines were released.

Persell’s co-investigators on this study were Donald M. Lloyd-Jones, M.D., assistant professor of preventive medicine and of medicine; and David W. Baker, M.D., associate professor of medicine and chief of general internal medicine at the Feinberg School.

Elizabeth Crown | EurekAlert!
Further information:
http://www.northwestern.edu

More articles from Studies and Analyses:

nachricht Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>