These findings set the stage for clinical research into stroke prevention
Among patients who have suffered a single stroke, researchers at the University of Pennsylvania School of Medicine, along with colleagues at other institutions, have found that severe stenosis, or narrowing, of the arteries in the head represents a major risk factor for the development of a subsequent stroke. Patients with recent symptoms were also at high risk. Further, women faced a greater risk of subsequent stroke than men. Their work, to be published in the January 31 issue of Circulation, lays the foundation for further studies into effective therapies to prevent secondary strokes.
The researchers findings are part of a larger multi-site clinical investigation - specifically, the Warfarin versus Aspirin for Symptomatic Intracranial Disease (WASID) trial - which found aspirin to be the preferred medical therapy for preventing a secondary stroke. (Indeed, according to the WASID study, warfarin was associated with significantly higher rates of adverse events and provided no benefit over aspirin for preventing stroke and vascular death.)
Kate Olderman | EurekAlert!
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