Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Weight loss improves bladder control in women with prediabetes

30.01.2006


Diabetes prevention study reveals another benefit of lifestyle changes

Losing a modest amount of weight through dietary changes and increased physical activity reduces the occurrence of urinary incontinence (UI) in women with prediabetes, a condition in which blood glucose levels are higher than normal but not yet diabetic. This finding comes from a new study, published in the February issue of Diabetes Care, of women who participated in the Diabetes Prevention Program (DPP), a landmark clinical study funded by the National Institutes of Health (NIH).

Launched in 1995, the DPP’s main results were announced in 2001 and reported in 2002 [http://www.nih.gov/news/pr/feb2002/hhs-06.htm]: losing 5 to 7 percent of weight through diet and a consistent increase in physical activity (e.g., walking 5 days a week 30 minutes a day) reduced the onset of type 2 diabetes by 58 percent. Treatment with metformin lowered the chances of developing diabetes by 31 percent.



"To combat the dual epidemics of obesity and type 2 diabetes, Americans need to know about the proven benefits of losing some weight through calorie reduction and increased physical activity," said NIH Director Elias A. Zerhouni, M.D.

The DPP randomly assigned 3,234 overweight people with higher-than-normal blood glucose levels to one of three approaches to prevent type 2 diabetes: dietary changes and increased physical activity aimed at a 7-percent weight loss; treatment with the oral diabetes drug metformin; or placebo. The last two groups were also given standard medical advice about diet and weight loss. In the study, 660 women were randomly assigned to intensive lifestyle changes, 636 to metformin treatment, and 661 to placebo. Their average age was 50 years old, with an average body mass index of 35 (e.g., a 5’ 4" woman weighing 204 pounds).

Women who implemented intensive lifestyle changes and lost 5 to 7 percent of their weight had fewer episodes of weekly incontinence compared to those in the metformin or placebo groups (38 percent vs. 48 percent vs. 46 percent, respectively.)

"Our findings reinforce the DPP’s good news about the benefits of modest weight loss. A 200-pound woman who loses 10 to 15 pounds not only lowers the risk of developing type 2 diabetes but also improves bladder control," said lead author Jeanette S. Brown, M.D., of the University of California, San Francisco. "If you’re a woman at risk for type 2 diabetes, preventing or delaying diabetes and improving bladder control are powerful reasons to make these lifestyle changes."

Weight loss was particularly effective in reducing episodes of stress incontinence--leakage of small amounts of urine during physical movement, such as coughing, sneezing, and exercising. Stress incontinence results, in large part, from a weakening of the pelvic floor muscles that support the bladder. Though researchers do not fully understand all the factors contributing to stress incontinence, it is linked to obesity, diabetes, and other conditions, such as pregnancy, which increase pressure on the pelvic floor. In the DPP participants, weight loss did not alleviate urge incontinence--leakage of urine at unexpected times. Urge incontinence is more closely linked to overactive nerves that control the bladder, sometimes triggering inappropriate contractions.

More than 13 million people in the United States, mostly middle-aged and older women, experience loss of bladder control. Overweight women and those with type 2 diabetes have a 50- to 70-percent increased risk of incontinence. In the National Health and Nutrition Examination Survey 2001-2002 sample, one out of three women with diabetes or prediabetic glucose levels reported weekly or more frequent episodes of UI.

Some studies have reported that increased physical activity worsens incontinence, but DPP participants randomly assigned to lifestyle changes, who typically chose walking as their physical activity, did not have increased problems with incontinence.

"Urinary incontinence is a costly, socially isolating condition that impairs quality of life and takes a psychological toll on many women. For women at risk for type 2 diabetes, losing a modest amount of weight is likely to alleviate incontinence, especially stress incontinence," said Leroy Nyberg, M.D., Ph.D., of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which funded the study.

Nearly 21 million people in the United States--7 percent of the population--have diabetes, the most common cause of blindness, kidney failure, and amputations in adults and a major cause of heart disease and stroke. Type 2 diabetes accounts for up to 95 percent of all diabetes cases. The prevalence of type 2 diabetes has risen dramatically in the last 30 years, due mostly to the upsurge in obesity. In addition, about 40 percent of U.S. adults ages 40 to 74--41 million people--have prediabetes, which raises the risk of developing type 2 diabetes and cardiovascular disease.

Joan Chamberlain | EurekAlert!
Further information:
http://www.ndep.nih.gov/campaigns/SmallSteps/SmallSteps_index.htm
http://www.nih.gov

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>