In the continuing battle against antibiotic resistance, two new studies shed light on the complex defense mechanisms pathogenic bacteria use to evade antibiotic attack, an understanding of which could lead to new, more effective antibiotics to help save lives and combat the growing problem of antibiotic resistance. The studies, both of which target chemical components in the protective membrane surrounding bacterial cells, will appear in the February 17 inaugural print issue of ACS Chemical Biology, a new monthly publication of the American Chemical Society, the world’s largest scientific society.
In one study, researchers from the University of Michigan College of Pharmacy in Ann Arbor and the Borstel Research Center in Germany genetically engineered a strain of E. coli so that it lacks its normal outer protective layer of lipopolysaccharides, complex structures that help them defend against antibiotic attack. Removal of this layer is believed to make E. coli and other gram-negative bacteria more vulnerable to antibiotic attack, the scientists say.
"The study is further proof-of-principle that the spectrum of activity of antibiotics can be significantly extended by targeting the formation of lipopolysaccharides in the outer membrane," says study co-author Timothy C. Meredith, Ph.D., a medicinal chemist who conducted the research as a doctoral student at the University of Michigan with Ron Woodard, Ph.D., a professor of medicinal chemistry at the university. Meredith is currently a researcher at Harvard Medical School in Boston.
Michael Bernstein | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Physics and Astronomy
24.05.2018 | Health and Medicine
24.05.2018 | Life Sciences