Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify target for therapeutic drugs to fight most common adult brain cancer

16.01.2006


A research team at UT Southwestern Medical Center has discovered a cell-signaling mechanism instrumental in the most common brain cancer in adults.



The study, published in today’s issue of the journal Cancer Research, opens an avenue to develop therapeutic drugs to target the epidermal growth factor receptor genes that play a major role in the development of deadly brain tumors, researchers said.

The median survival of patients with glioblastoma multiforme (GBM), a cancer of the supportive tissue of the brain, currently is about one year after diagnosis with the best treatments available, said Dr. Amyn Habib, assistant professor of neurology at UT Southwestern and the study’s senior author. GBM, which accounts for 60 percent of brain tumors in adults older than 50 years, can infiltrate the brain extensively and sometimes becomes enormous before turning symptomatic.


Researchers have known for years that tumor cells proliferate out of control by a mechanism characterized by an abnormally high number of copies of the epidermal growth factor receptor gene (EGFR). This overexpression of EGFR, Dr. Habib said, is a striking feature of glioblastoma multiforme, present in 40 percent to 50 percent of tumors and results in an uncontrolled multiplication of both normal EGFR and a mutant form called EGFRvIII.

While studying human brain tumor tissue and human brain tumor cells from cell lines grown in the laboratory, Dr. Habib and his colleagues discovered that EGFRvIII generates a unique pattern of signaling (distinct from normal EGFR) that causes brain cancer cells in GBM to grow and multiply unchecked.

"The better we understand the signaling mechanisms of the normal and the mutant EGFR, the better we can manipulate or control them," Dr. Habib said. "Our findings suggest that you have to target both the mutant and the normal EGFR based on the mechanism we described."

Current standard treatment of GBM consists of surgical removal of the tumor, followed by radiation and chemotherapy. Dr. Habib said he hoped the findings gained from the new study could eventually lead to therapeutic drugs that destroy brain cancer cells and spare healthy cells.

Other UT Southwestern researchers on the study were Dr. Deepti Ramnarain, postdoctoral researcher in neurology and lead author; Dr. Seongmi Park, postdoctoral researcher in neurology; Dr. Kimmo Hatanpaa; assistant professor of pathology; Dr. Jack Raisanen, associate professor of pathology; Dr. Raheela Ashfaq, professor of pathology; and Shane Scoggin, research assistant in the Harold C. Simmons Comprehensive Cancer Center. Researchers from Beth Israel Deaconess Medical Center and Harvard Medical School also participated.

Toni Heinzl | EurekAlert!
Further information:
http://www.utsouthwestern.edu
http://www.utsouthwestern.edu/findfac/professional/0,2356,61448,00.html
http://www.utsouthwestern.edu/receivenews

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>