An inhaled anti-rejection drug can dramatically improve survival after a lung transplant, according to a study conducted at the University of Pittsburgh and led by lung disease specialists who are now at the University of Maryland in Baltimore. The results of the study are published in the January 12, 2006 edition of the New England Journal of Medicine.
The study, which was the first double-blind, placebo-controlled trial ever conducted in lung transplant patients, tested an inhaled form of cyclosporine, a widely used medicine to prevent organ rejection following a transplant. The study, conducted from 1998 to 2001, was funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
"Inhaled cyclosporine is the first drug ever to show a decline in the incidence of chronic rejection--the leading cause of death following a lung transplant," says lead author Aldo T. Iacono, M.D., medical director of lung transplantation at the University of Maryland Medical Center and associate professor of medicine at the University of Maryland School of Medicine.
Ellen Beth Levitt | EurekAlert!
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