Yale School of Medicine researchers report in Nature Immunology how infection fighting mechanisms in the body can distinguish between a virus and the healthy body, shedding new light on auto immune disorders.
The infection fighters in question, toll-like receptors (TLRs), function by recognizing viral, bacterial or fungal pathogens and then sending signals throughout the immune system announcing that an infection has occurred.
Viruses change features to avoid being recognized, thereby triggering the immune response. But TLRs recognize the highly conserved features of pathogens, features that are often difficult to change without affecting the punch of the pathogen, said lead author of the study, Gregory Barton of the University of California at Berkeley who performed the research while in the Section of Immunobiology at Yale School of Medicine.
Jacqueline Weaver | EurekAlert!
Further information:
http://www.yale.edu
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