Chances are good that a medication you take is one of several drugs that can be affected by genetic factors, according to researchers at Washington University School of Medicine in St. Louis and the St. Louis College of Pharmacy. They found that 29 percent of patients seen at local primary-care offices had taken at least one of 16 drugs that can cause adverse reactions in genetically susceptible people.
Finding that so many primary-care patients use such medications suggests that pharmacogenetics—the study of the interplay between genes and drugs—has the potential to benefit a large portion of the population, according to the researchers. Applying information from pharmacogenetics to primary-care practices could reduce the incidence of adverse reactions and optimize treatments, according to the study, published in the January 2006 issue of the journal Pharmacogenomics.
"Until now, researchers looking at the role of genetic variation in drug effects have focused mainly on toxic drugs used by specialists treating cancer or HIV infection," says Howard L. McLeod, Pharm.D., director of the pharmacology core at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "We knew that some of the drugs commonly used in the family practice setting can cause adverse reactions in people who have certain genetic variations, so we measured just how often these drugs are used."
Gwen Ericson | EurekAlert!
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