Researchers at the University of California, San Diego (UCSD) School of Medicine took a step closer to understanding the basis of a severe epilepsy and mental retardation syndrome with work published in the January 5, 2006 issue of the journal Neuron.
Joseph Gleeson, M.D., Director of the Neurogenetics Laboratory at the UCSD School of Medicine and associate professor in the Department of Neurosciences, and his research team have developed a mouse model for a severe brain disorder in newborn children called lissencephaly, or "smooth brain."
"This is the first study to establish a link between the human and mouse disease that clearly shows we can model this condition in the lab," said Gleeson. "This study will allow us to begin to better understand what goes wrong in lissencephaly, and to use this mouse to figure out why children with this disease develop seizures and mental retardation."
Debra Kain | EurekAlert!
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