Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Animal research suggests perimenopause is a critical time for women’s health

06.12.2005


Research in monkeys suggests that the perimenopause – the five to 10 years before a woman’s menopause – is a critical time for preventing heart disease and osteoporosis.



"Research in animals suggests that the five years before menopause are when bone is lost and when heart vessel disease begins to accelerate," according to Jay Kaplan, Ph.D., from Wake Forest University Baptist Medical Center, who spoke today at the annual meeting of the American College of Veterinary Pathologists in Boston. "Waiting until menopause is not the time to start thinking about prevention."

Kaplan, a professor of comparative medicine, was invited to summarize his extensive research on how hormone levels affect health. His work has focused primarily on how stress during the younger years can interfere with ovulation and reduce estrogen levels, which can set the stage for heart disease later in life.


"But, this isn’t just a problem in younger women," he said. "At perimenopause, all women are affected by variably changing and ultimately declining estrogen levels. Perimenopause is a time of increased vulnerability to chronic disease."

Women have traditionally been considered immune from heart disease until after menopause, when their estrogen levels dramatically drop. However, Kaplan’s research has shown that in monkeys, the process starts much earlier. He found that stress in the younger years can reduce estrogen levels and lead to the buildup of fatty deposits in the blood vessels (atherosclerosis) that can lead to heart attacks and strokes.

"Our research adds to the growing body of evidence that cardiovascular health after menopause is influenced by hormone levels many years earlier," said Kaplan. "Our monkey studies showed that a deficiency of estrogen before menopause places these females on a high-risk trajectory, even if they got estrogen treatment after menopause."

For women in perimenopause who intend to take hormone therapy, Kaplan said the research suggests that perimenopause may be the best time to start.

"The results emphasize that primary prevention of heart disease should start pre-menopausally," he said.

Kaplan’s animal studies found that treating the estrogen-deficient monkeys with estrogen before menopause markedly slowed the growth of atherosclerosis. Kaplan said the findings were consistent with the hypothesis that estrogen inhibits the development of vessel disease, but may be ineffective if the disease already exists.

"Applied to women, this lifetime study suggests that having an estrogen deficiency in the pre-menopausal years predicts a higher rate of heart disease after menopause, even when treated with hormone replacement therapy after menopause," said Kaplan.

Kaplan said that some physicians advocate women taking oral contraceptives right up until menopause, and then beginning hormone therapy. He said animal research suggests that oral contraceptives can be effective in heart disease protection.

However, the Women’s Health Initiative, the largest study to date to test the effectiveness of hormone therapy in women, found that treatment with combination therapy (estrogen and progestin) increased risk of breast cancer, heart attacks and stroke. As a result of the study, many doctors advise that women not take hormone therapy to prevent heart disease.

But critics of that study say it didn’t involve enough younger women to see if taking the drugs earlier can be effective for prevention. A theory that there is a "window of opportunity" for hormone therapy to be effective for prevention is being tested in a five-year study of peri-menopausal women ages 45 to 54. Funded by the Kronos Longevity Research Institute, the study is evaluating an oral tablet containing estrogen, a skin patch delivering estrogen and a placebo.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>