Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Multiple-birth babies, boys have higher risk of defects

23.11.2005


Twins, triplets and other multiples have a nearly 50 percent greater chance of being born with birth defects, and boys tend to be more at risk than girls, according to two population-based studies conducted at the University of Florida.



UF researchers who studied all Florida births from 1996 through 2000 found multiples have a higher risk than babies born singly of developing 23 of 40 birth defects, such as spina bifida, according to results recently published online in the Maternal and Child Health Journal.

The same team of researchers, from UF’s Maternal Child Health Education Research and Data Center, studied 4,768 pairs of opposite-sex twins and found that boys had a 29 percent higher risk for birth defects than girls. This could be because boys tend to develop at a slower pace, leaving a little more time for potential problems to arise, according to findings published this month in Birth Defects Research (Part A): Clinical and Molecular Teratology.


"In the past 20 years, multiple births have increased because of greater reliance on assistive reproductive technology, especially among women delaying childbirth until their 30s and 40s," said Yiwei Tang, M.D., an assistant professor of pediatrics and a lead researcher on both studies. "In offering these options to women, full disclosure of an increased risk of birth defects should be made."

Multiples had the highest risks of having certain brain, heart, bladder and liver defects.

Although the risks are greater for multiple-birth babies, the number of children born with birth defects is still small. About 3.5 percent of multiples are born with birth defects, whereas 2.5 percent of single-birth babies are, the research shows.

"Though birth defects are not a common occurrence, when they do occur within a family, it can be life-altering," said Jeffrey Roth, Ph.D., an associate professor of pediatrics, director of the data center and a study co-author. "For the affected family, it doesn’t matter that what has happened to them is a rare event."

The team analyzed years of data from Florida Birth Vital Statistics and the Florida Birth Defects Registry, studying 972,694 births for the multiple-birth study. Of those, about 28,000 were multiples, about 3 percent of all births.

"The strength of population-based research is that all women in Florida who gave birth during this time period were taken into account," Roth said.

Among twins, boys were twice as likely as their sisters to have defects of the genital and urinary organs and five times as likely to be born with an obstruction between the stomach and small intestine. But congenital hip dislocation was 10 times more common among girls.

Previous research has shown that boys tend to be more susceptible to birth defects, but little was known about defects among opposite-sex twins, who develop in the same environment and have similar risks for genetic defects, said Christine Cronk, Sc.D., an associate professor and leader of the birth defects epidemiology team at the Medical College of Wisconsin.

"(The UF researchers have) speculated that certain birth defects, which occur very early in gestation, have to do with developmental speed in males and females," Cronk said. "The assumption is that if (the baby) is further ahead in development, that would serve as protection against defects."

Because older mothers naturally have an increased risk of giving birth to children with birth defects, the researchers used statistical models to factor out age, race and even education levels that could have led to inaccurate results, Tang said. This way, they only compared babies born to similar mothers, Tang said.

This information allows prospective parents, especially those considering fertility treatments that will increase their odds of having multiple children, to make more informed choices, said Michael Resnick, Ed.D., a pediatrics professor and a co-author of the study.

Informed decisions also increase the chances that parents and their physicians will be prepared to provide the best care should children be born with birth defects, Resnick said.

"This study adds to the knowledge to help genetic counselors, psychologists and physicians to better prepare parents as to what the outcomes might be," Resnick said. "They can discuss this information and ask questions before deciding to start a family."

April Frawley Birdwell | EurekAlert!
Further information:
http://www.health.ufl.edu

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>