Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Multiple-birth babies, boys have higher risk of defects

23.11.2005


Twins, triplets and other multiples have a nearly 50 percent greater chance of being born with birth defects, and boys tend to be more at risk than girls, according to two population-based studies conducted at the University of Florida.



UF researchers who studied all Florida births from 1996 through 2000 found multiples have a higher risk than babies born singly of developing 23 of 40 birth defects, such as spina bifida, according to results recently published online in the Maternal and Child Health Journal.

The same team of researchers, from UF’s Maternal Child Health Education Research and Data Center, studied 4,768 pairs of opposite-sex twins and found that boys had a 29 percent higher risk for birth defects than girls. This could be because boys tend to develop at a slower pace, leaving a little more time for potential problems to arise, according to findings published this month in Birth Defects Research (Part A): Clinical and Molecular Teratology.


"In the past 20 years, multiple births have increased because of greater reliance on assistive reproductive technology, especially among women delaying childbirth until their 30s and 40s," said Yiwei Tang, M.D., an assistant professor of pediatrics and a lead researcher on both studies. "In offering these options to women, full disclosure of an increased risk of birth defects should be made."

Multiples had the highest risks of having certain brain, heart, bladder and liver defects.

Although the risks are greater for multiple-birth babies, the number of children born with birth defects is still small. About 3.5 percent of multiples are born with birth defects, whereas 2.5 percent of single-birth babies are, the research shows.

"Though birth defects are not a common occurrence, when they do occur within a family, it can be life-altering," said Jeffrey Roth, Ph.D., an associate professor of pediatrics, director of the data center and a study co-author. "For the affected family, it doesn’t matter that what has happened to them is a rare event."

The team analyzed years of data from Florida Birth Vital Statistics and the Florida Birth Defects Registry, studying 972,694 births for the multiple-birth study. Of those, about 28,000 were multiples, about 3 percent of all births.

"The strength of population-based research is that all women in Florida who gave birth during this time period were taken into account," Roth said.

Among twins, boys were twice as likely as their sisters to have defects of the genital and urinary organs and five times as likely to be born with an obstruction between the stomach and small intestine. But congenital hip dislocation was 10 times more common among girls.

Previous research has shown that boys tend to be more susceptible to birth defects, but little was known about defects among opposite-sex twins, who develop in the same environment and have similar risks for genetic defects, said Christine Cronk, Sc.D., an associate professor and leader of the birth defects epidemiology team at the Medical College of Wisconsin.

"(The UF researchers have) speculated that certain birth defects, which occur very early in gestation, have to do with developmental speed in males and females," Cronk said. "The assumption is that if (the baby) is further ahead in development, that would serve as protection against defects."

Because older mothers naturally have an increased risk of giving birth to children with birth defects, the researchers used statistical models to factor out age, race and even education levels that could have led to inaccurate results, Tang said. This way, they only compared babies born to similar mothers, Tang said.

This information allows prospective parents, especially those considering fertility treatments that will increase their odds of having multiple children, to make more informed choices, said Michael Resnick, Ed.D., a pediatrics professor and a co-author of the study.

Informed decisions also increase the chances that parents and their physicians will be prepared to provide the best care should children be born with birth defects, Resnick said.

"This study adds to the knowledge to help genetic counselors, psychologists and physicians to better prepare parents as to what the outcomes might be," Resnick said. "They can discuss this information and ask questions before deciding to start a family."

April Frawley Birdwell | EurekAlert!
Further information:
http://www.health.ufl.edu

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>