A collaboration of researchers, led by Dr. Martine Roussel (St. Jude Children’s Research Hospital), has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.
Their study will be published in the November 15th issue of Genes & Development, but will also be made available online ahead of print on 10/31.
In their upcoming paper, the authors identify a heretofore unknown role for the cyclin-dependent kinase inhibitor, INK4C, in mediating medulloblastoma development, independent of p53 status. Using Ink4c-mutant mice, Dr. Roussel and colleagues demonstrated that Ink4c inactivation cooperates with mutations in Patched (Ptc1, a Shh receptor) to stimulate medulloblastoma formation, even when the p53 gene is intact.
Heather Cosel | EurekAlert!
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