Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Largest single-institution study demonstrates Mammosite is a safe breast cancer treatment

19.10.2005


Treating breast cancer with MammoSite® resulted in a low risk of complications and was generally well tolerated, according to a University of Pittsburgh School of Medicine study presented today at the 47th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Denver.



MammoSite, a type of breast brachytherapy (bray-kee-therapy), uses a single catheter inserted into the breast following lumpectomy, or surgical removal of a tumor, to deliver a high dose of radiation. Once the catheter is inserted, a tiny balloon is inflated and loaded with radioactive seeds that deliver prescribed levels of radiation to targeted tissue surrounding the tumor site.

"MammoSite is a type of partial breast irradiation that delivers radiation from the inside of the breast directly to the tumor site where cancer cells are most likely to reside," said Sushil Beriwal, M.D., assistant professor at the University of Pittsburgh School of Medicine and medical director of radiation oncology at Magee-Womens Hospital of the University of Pittsburgh Medical Center (UPMC). "Ours is one of the largest single-institution studies to confirm that it does this safely and with an acceptable level of toxicity."


The study, which was designed to evaluate early outcomes of MammoSite brachytherapy, and was approved by the FDA in 2002, evaluated toxicity in 100 patients treated between June 2002 and October 2004 at the University of Pittsburgh Cancer Institute. The patients were followed between three and 30 months subsequent to treatment with an average follow-up time of one year. After treatment, patients were assessed at one week, one month and at three-month intervals. While 14 percent of women had to have the catheter removed because of various reasons, the majority of the patients (86 percent) underwent treatment.

Post-treatment complications included balloon rupture, infections, skin toxicity and seromas (persistence of the cavity where the lump was removed). Study results indicated that balloon rupture occurred in six patients (7 percent) and wound infections occurred in 10 patients (12 percent). No patients had serious skin toxicities from treatment. A palpable seroma was observed in 34 of the patients (40 percent) and persisted beyond six months of treatment in 22 patients (26 percent).

The study also evaluated cosmetic outcome of MammoSite treatment. Cosmetic outcome refers to the physical similarity between the treated breast and the untreated breast. Forty-eight patients (56 percent) had excellent cosmetic outcomes; 32 patients (37 percent) had good cosmetic outcomes; and seven patients (7 percent) had fair cosmetic outcomes.

"Our findings demonstrate that the toxicities associated with MammoSite were similar to results reported in the MammoSite brachytherapy registry trial," said Dr. Beriwal. "The complications were acceptable and the cosmetic outcome was comparable to what we might see with standard external beam radiation." Dr. Beriwal added that follow-up studies will seek to assess the long-term effects as well as the efficacy of the treatment compared with standard external beam radiation therapy and other types of breast brachytherapy.

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Study shines light on brain cells that coordinate movement

26.06.2017 | Life Sciences

Smooth propagation of spin waves using gold

26.06.2017 | Physics and Astronomy

Switchable DNA mini-machines store information

26.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>