Combined therapy is good for BAD
A new research study published in the October issue of Cancer Cell identifies a molecular switch that integrates cell survival signals from multiple intracellular signaling pathways. The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better understanding of how these pathways converge to regulate the delicate balance between cell proliferation and cell death may lead to development of more effective cancer therapies.
A complex interplay between growth signals and apoptosis (programmed cell death) regulates cell proliferation. Activation of the epidermal growth factor receptor (EGFR) inhibits apoptosis, and EGFR mutations are associated with some human cancers. However, inhibition of EGFR expression has not been widely successful as a cancer treatment because, in many cases, mutations occur in signaling molecules downstream of EGFR, such as the tumor suppressor PTEN. Dr. Neal Rosen and colleagues from Memorial Sloan-Kettering Cancer Center in New York examined interplay between cell proliferation signals in tumor cells with PTEN mutations.
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
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