When added to standard treatment, steroids significantly reduce the odds of developing heart damage in children with Kawasakis disease, according to a study in the October issue of Pediatrics. These findings address a gap in knowledge. Current guidelines from the American Academy of Pediatrics state that the evidence for steroid treatment is lacking and recommend the standard treatment for Kawasakis, which is aspirin and intravenous immunoglobulin (IVIG).
"This gap in knowledge led us to examine the benefits of steroids more closely. We looked at research worldwide and were surprised to find eight solid clinical trials showing the value of steroids in significantly reducing heart damage in children with Kawasakis disease. Steroids, when combined with aspirin and IVGB, reduced the odds of developing inflammation of the heart blood vessels by half," said Stephen Aronoff, MD, lead author of the meta-analysis and Temple University School of Medicine professor and chair of pediatrics.
Aronoff hopes that a multi-center study, currently underway, will provide further evidence of the benefits of steroid treatment for Kawasakis disease. Also needed is more evidence about the most effective types and doses of steroids.
Eryn Jelesiewicz | EurekAlert!
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