Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds overall health and quality of life intact 10 years after stem-cell transplantation

19.09.2005


Survivors of stem-cell transplantation for blood cancers can expect to be just about as healthy 10 years later as adults who have never had a transplant, according to a new study by researchers at Fred Hutchinson Research Cancer Center.



The findings, to be published in the Sept. 20 edition of the Journal of Clinical Oncology, is the first of its kind to follow a large group of patients from before their transplant through the 10-year post-transplant period.

"In many areas of health, our survivors are undistinguishable from case-matched controls who participated in this study and had not had a transplant," said lead investigator Karen Syrjala, Ph.D., head of the Biobehavorial Sciences group in the Hutchinson Center’s Clinical Research Division.


For example, the study found that transplant survivors and case-matched controls reported similar rates of hospitalization and outpatient medical visits. They had similar rates of diseases and conditions such as asthma, diabetes, high blood pressure, high cholesterol, osteoporosis and hypothyroidism, and they had similar psychological health, marital satisfaction and employment.

However, Syrjala and colleagues also found that transplant patients had a higher incidence of musculoskeletal problems, such as stiffness and cramping; poor long-term sexual health; and increased urinary frequency and leaking than the control group. Long-term survivors also had higher use rates of anti-depressant and anti-anxiety medications even though reported rates of depression and anxiety were about the same as that of the control group.

The study also reported potentially under-diagnosed problems among survivors such as the bone-thinning disease osteoporosis and hypothyroidism because the reported rates of these diseases were lower than expected.

The researchers urge primary care providers to routinely screen for these problems, which might otherwise be considered relevant primarily to older populations, Syrjala said. The median age at transplant of the patients surveyed was 36.4 years.

In all, survivors reported an average of 3.5 medical problems versus 1.7 for controls, even though survivors and controls had similar rates of hospitalization and outpatient medical visits.

Syrjala and colleagues made an important and positive observation among 10 percent of the survivors who had suffered relapse and were in complete remission at the time of the study. "The fact that patients can relapse and still have healthy, full lives 10 years later and look like everyone else who has gone through a transplant without relapse is really good news," she said. "In the past, relapse after a transplant was always thought to be a very bad sign for quality of life."

All of the patients in the study were transplanted at the Hutchinson Center between March 1987 and March 1990. More than 400 patients consented to the study and after 10 years 137 transplant survivors and an equal number of controls completed a self-report of medical problems, symptoms and health-related quality of life. Most of those surveyed had been treated for leukemia or lymphoma. More than three-quarters received donor cells from a matched relative. There was an almost equal split between males and females.

Survivors were asked to nominate a case-matched control participant, ideally a biologic sibling of the same gender and within five years of age; this was achieved in 60 percent of the controls.

The study survey asked participants about 85 diseases and symptoms and to indicate whether they had these problems now, whether the diseases or symptoms were ever a problem in the past 10 years or were no longer a problem. Twenty-seven diseases or conditions emerged as the most prevalent and were included in the final analysis. They ranged from asthma to second cancers.

"Ten years after HCT (hematopoietic cell transplantation), the 137 survivors were indistinguishable from case-matched controls in many areas of health and psychosocial functioning, although survivors reported a greater number of medical problems and greater limitations in sexuality, insurance and social, emotional and physical roles," the authors wrote. "Some of these problems are known to be associated with HCT, while others have not been recognized previously as late concerns."

This type of research is important, Syrjala said, because the number of long-term survivors of stem-cell transplantation is increasing rapidly. For example, patients with acute leukemia or chronic myeloid leukemia who survive without recurrent malignancy for two years after allogeneic stem-cell transplantation (the infusion of stem cells from a donor) have an 89 percent probability of surviving for five or more years. More than 45,000 people worldwide receive stem-cell transplants each year.

The study is important also because information on 10-year survivorship has been sparse. "Although research on late effects has increased, systematic information has not been available to guide oncologists or primary care physicians in routine monitoring and management of health-care needs after 10 years in this population," the authors wrote.

Kristen Woodward | EurekAlert!
Further information:
http://www.fhcrc.org

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>