Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. The findings, published in the latest issue of Cancer Research, suggest that a diet enriched in such foods could help prevent cancer, while the inhibitor offers a new tool for anti-cancer therapy.
Phosphoinositide 3-kinase is a key player in the development and progression of human tumours. Scientists have been exploring phosphoinositide 3-kinase as a target for cancer treatment but inhibitors have been difficult to develop because of problems with the chemical stability and toxicity of the inhibiting substances. Now, a team of scientists led by Dr Marco Falasca of the UCL Sackler Institute have discovered that a natural compound, inositol pentakisphosphate, inhibits the activity of the enzyme, suggesting it could be used to develop new treatments for cancer.
In the study, the compound was tested in mouse models and on cancer cells. Not only was it found to inhibit the growth of tumours in mice, but the phosphate also enhanced the effect of cytotoxic drugs in ovarian and lung cancer cells. The findings suggest that inositol pentakisphosphate could be used to sensitize cancer cells to the action of commonly used anti-cancer drugs.
Jenny Gimpel | EurekAlert!
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First form of therapy for childhood dementia CLN2 developed
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A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
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At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
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