Researchers at Yale School of Medicine provide direct evidence that two parts of a neuronal system, one that promotes eating and another that suppresses eating, are critical for the acute regulation of eating and body weight, according to a study published online in the September 11 issue of Nature Neuroscience.
The paper makes it clear that the agouti-related peptide-expressing (AgRP) neurons are mandatory for eating. "Previous studies showed that the brain, particularly the hypothalamus, is responsible for the regulation of eating," said co-senior author Tamas Horvath, chair and associate professor in the Section of Comparative Medicine, and associate professor in neurobiology and the Department of Obstetrics, Gynecology & Reproductive Sciences. "But until now, no experimental evidence was available to prove that AgRP neurons are critical for acute regulation of eating."
Horvaths collaborator Jens Bruening of the University of Cologne in Germany introduced the avian diphtheria toxin receptor into neurons in the feeding support system of transgenic mice. When the animals were adults, two injections of toxin caused the specific cell population to die within 48 hours, impairing the mouses ability to eat and resulting in acute anorexia. These mice also showed marked reduction in blood glucose, plasma insulin and Leptin concentrations.
Karen N. Peart | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy