Yale School of Medicine researchers published a report this month in the Archives of General Psychiatry that highlights the interplay of two brain signaling systems, glutamate and dopamine, in psychosis and cognitive function.
The study helps resolve a long-standing research debate between the "dopamine hypothesis" and the "glutamate hypothesis" or "PCP Model," said John Krystal, M.D., professor, deputy chair for research in the Department of Psychiatry, and lead author of the study. "Both systems appear to be involved," he said.
The first theory suggests that dopamine neurons are hyperactive in persons with schizophrenia and that effects of the dopamine-releasing drug, amphetamine, can mimic aspects of the illness. The second theory maintains that certain schizophrenia-related deficits in the function of glutamate, the dominant stimulatory transmitter, could be reproduced in healthy people by the administration of drugs such as ketamine, which block the NMDA subtype of glutamate receptors.
Jacqueline Weaver | EurekAlert!
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